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Database: UniProt
Entry: I7M136_TETTS
LinkDB: I7M136_TETTS
Original site: I7M136_TETTS 
ID   I7M136_TETTS            Unreviewed;      2860 AA.
AC   I7M136;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR94170.2};
GN   ORFNames=TTHERM_00522370 {ECO:0000313|EMBL:EAR94170.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR94170.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662717; EAR94170.2; -; Genomic_DNA.
DR   RefSeq; XP_001014415.2; XM_001014415.2.
DR   STRING; 5911.EAR94170; -.
DR   GeneID; 7838708; -.
DR   KEGG; tet:TTHERM_00522370; -.
DR   InParanoid; I7M136; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50919; MIR; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2405   2425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2446   2468       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2556   2584       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2605   2627       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2689   2708       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      176    229       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      321    380       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       87    107       {ECO:0000256|SAM:Coils}.
FT   COILED      139    166       {ECO:0000256|SAM:Coils}.
FT   COILED      993   1037       {ECO:0000256|SAM:Coils}.
FT   COILED     1105   1132       {ECO:0000256|SAM:Coils}.
FT   COILED     1777   1801       {ECO:0000256|SAM:Coils}.
FT   COILED     2818   2845       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2860 AA;  337893 MW;  0DA60411C1413520 CRC64;
     MSQEENNYLR FGDKIVIKGF LSRGQQDYGG FLCAKGFTQS NISFQVIPND ILQKSSEYTN
     NLSFLKNYND FVFQIWPRLN FQASKEYRHH QKRVDYLQKN IEKLVQDNKR RTQRHIAESY
     TETQKIKLKK MDTKLDVDLQ KLIDEKDQYE SISQTLKENV QRENEMNLKS LNQFQGQPVG
     YGTEIQIMHV DSGLFLSSQT IASDSEKSAY KFQLSKDYSS GMIFRILPKY RLRNIGDTIQ
     YRDQMIIQSV KLRFSVSFSE EQAEIGKNKQ PVQDFNEYKQ VEEKKNDKIS FIIDTYISQY
     SEVAWEFRKY STCSSQNNLP KSVISGGDFV RFFHSETEGY LTADIAYQNQ LLPQVYLGNY
     NGTYEQEKYS ISSVWQIEQI NDYNKGGPIS ISQDSESVFF YLRHVQTGRL LSFNQGGFSL
     DQDKDNIQQL DYQNAFVQFI QTKASDIQYL ENQQSYHISI LKNYMDITKE PEQVLENNEN
     VQIPGFYQGL KDKEFNFNRQ IINSDLEIND ENALQIQKLS EQEKSDILFS LSAQPVLIKF
     VNIFKYKQSS DLITHDLKQK VTQSLEQLIR FVCELNSLDE TKGILDCQGF CIQKNQRLLK
     DCQFIQILTS LLYYPFKNNY YNPKNLKLLP KDIIYIFQLT NVLIKYIIRE YRPNELFASQ
     WLELLMEQAM EYDNDVDILA EPTLTELIDN NEYILKYKID ENIILKFVEL LIKEKSIKFI
     KLLRALINCD NKAMKNNQDT VITKLLFENN QAENFINPLS MLQNGKIQIR IREVPYDLEQ
     IKQIHSREVN EYMKFYINVI YLFSDLCMDK QFIAIEFLSK YFSYDICYTI ISGQEFDMDL
     KSAFCSFMRT CYIEGLHLNP IQAPIYLKQW DLIYSPKGEL QWQKQLENMT KIMNQNKLVN
     AGFYGQRYVP SYSENPDILQ CQYYIEKFDN LKDFIQLYLN QITDEQLYQR IWETEFNEFT
     LNIIKICSSL FTYGMYNTIS QINQILAPLI KFLDASRDVL SEQEEKILKK EQKIKKIQQK
     SAELQQLEEK KENKISKKFN RYNQTEESMI LCQCRTNICE ILDFANNIIL NWMGDKILIQ
     FKKFYEESNL ETKSVQQILQ MIKERNNYLK AVQDFKNDKN ELKEKRDKEQ ILIPPFDLLQ
     QPLDWINDRV QDTFFTIDSL VQKKKGSKNP LDKTINIYLI DLLLYENSDL VESAMQILQA
     NFSKRYNLVE YLKEIQIIDD SHKISILQKA QENYYRLNNL VDDSEEWYGL NSERGQQNSQ
     IMLEILDELF YFLTDSQIRQ VTEIDEVVSQ KQSSKKKFLQ VDDNGDDEDP QLQLIENDDQ
     DPYNDQGIMH DEFSSEHSII QDKLNQLISS DINQKGISIN EDYYHEFVLK KHIRQEIQKM
     FRLLQIHKPI VQMLLYDLEW LKQIEKVKSQ AILKKCFKIL SLFCFDNIQN QQQLAEYIDC
     FIGHLQKETN TLPQMLLNEI ARNNEELLTD HKLVHKLIES YCKIINHQTS NNQQRTIMLE
     YLSNFMKFKG QVIRQNQIDV MLCLSNPKYK FILFQLGLGN IQQDNTFYLQ CNQLSQQIEN
     GLKSNTPQVC IPMPNELQYF IQQLELMSTA CEEKNGITEN KSQNYFPLEV IYELLQQTPK
     CWPIRRAVVQ FFYHVFLETE KDIEDLEYIQ KILFLIQSDL EYISNNIKQL EDSQVYVINF
     QGNTSLRSLI QVYTFGLLFY CVKESAERYL INQKEQVYSF YKSIIQSFVK LQAILTDKDE
     CNKVFIAQVF FIIQQKRHIQ KSSLEIKELK EHFLPEIKDL IKKYENQQIN HNKQNNQSNQ
     QKQDLSKYGK LQQLPLKFHI IFKKLSETQI FKQCEEQEFQ DLSQTMKKIQ ILSKNTLKNN
     NIISFEQLCK KFCSIMNPQN TNLPDQYYLL GLKIFRNLIE EENSGEAQPA AEWDGQLSFQ
     SLVIQRQNTL TDYGVIQVVC NFLNANFKAE IKNEAILLGI AMLYGGNQKC QQELFNCLMQ
     DSNNTVMICL FQMIQNYSTK IKKQMSFRNQ EFQEKFRQRI HDLKAKKNNS DNVLINNDYD
     EQKEKEAKEK EEQMLIVQEV QGQINAYEED EIILNLKRIY RFLQLFCEGH FLPLQDFLRE
     QKQNGNLNPQ SINFIKTISQ NFGSLIRYLN DKTIDLGQQM IDLLIESLQG PCQLNQKCLS
     DNRIVDYIKE LLSTFNQESD YEKRGIVEDD LKDQIDEMVS KSTILLVSLL EGNTEQQIPL
     YIDQQLDYGF IRQFLTNQFQ QFVTEDLEMN IRNVSIKEII ERVSEKQQEF TGQIEMAFNM
     FILLATISDQ LKRLNPDLVS EAQKCIEQKT ENIEDQAIEF FSQNTCNIEV FFQDKICRVF
     FVKHPACRNI SKHSREEFMN EVERGTLNDK LGSLMEEAET FFTEMDHMTQ LKGWIIHFTS
     ERYKMLKWFS TIVVFAINIT MIASFERKLQ EGYTVIDRSQ TASTQVIYAL GIIQLVTNFI
     MMMFWLVVNG PMVLTQKWRK YNEENQYLLD PKQERLLEEL DNPKYYSTQL VTYALKTKGP
     NYPKFQQNSF LRFGNLWGQV KYYESSFMFM LKDGSFVYLC FYISCTVLGF FFDNIVYSIQ
     LLDIINQFPS LKNVTRAVQL NANQLLKTLL LGIIVIFIFS VVGYTFAVDS FFSEEIGHGE
     NMCSNLFQCF IDTLNYGLRT DGGISNTLRR QSFEFDNRGT YIFRVIYDVS WFALINVIFI
     NIIFGVIIDT FGQLRDKKRE VIEDMKNVCF ICGLERYVFD KHADGFNNHI ERDHQLWNYI
     FYMYYLSKKD STDFNGVETE VIQKIKNEDI SWFPMMKSLS LGEIEKKNGL GDKVINNLDE
     MSDSFKDLQE KIIFLQTQLK KEQQMNKIQQ KALNSVSQIC
//
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