ID I7M1I0_TETTS Unreviewed; 365 AA.
AC I7M1I0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Zinc-binding alcohol dehydrogenase family protein {ECO:0000313|EMBL:EAR96382.1};
GN ORFNames=TTHERM_00189510 {ECO:0000313|EMBL:EAR96382.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR96382.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662693; EAR96382.1; -; Genomic_DNA.
DR RefSeq; XP_001016627.1; XM_001016627.1.
DR AlphaFoldDB; I7M1I0; -.
DR STRING; 312017.I7M1I0; -.
DR EnsemblProtists; EAR96382; EAR96382; TTHERM_00189510.
DR GeneID; 7834799; -.
DR KEGG; tet:TTHERM_00189510; -.
DR eggNOG; KOG1198; Eukaryota.
DR HOGENOM; CLU_026673_3_0_1; -.
DR InParanoid; I7M1I0; -.
DR OrthoDB; 5473274at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08252; AL_MDR; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR014182; ADH_Zn_typ-1.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR NCBIfam; TIGR02817; adh_fam_1; 1.
DR PANTHER; PTHR48106:SF8; QUINONE OXIDOREDUCTASE PIG3; 1.
DR PANTHER; PTHR48106; QUINONE OXIDOREDUCTASE PIG3-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 19..342
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 365 AA; 40265 MW; 0B07330562303B87 CRC64;
MAQITPAIIK AIGLKDPKGD LSLIEVPLKQ LGSKDLLVRI EAVSVNPVDY KKLQSIRTQN
ISQDNPVILG FDASGVVVKI GSDCKLFNVG DQVIYSGEYT KHGSNANYQI VDERIVGNKP
RKLSHAEAAA IPLVSLTAYE GIVEEMRISP TEKQHNQNKN ILIVGAAGGV GSSAIQIAKK
FLGLTVIATA SRKESIDFCK KMGADFVINH QNPLAEELNK LNISSLDYIF NCVEMKSSYF
EQFASLIKPF GRIVGVVGFD EPLNLQLLFL KRAKISIECM FTRSMFGEQP EKQNQILNKI
SELYDKGILI PTVQKQKQFS LDSLIDAHNL SKSGKTVGKI SLFDVQSFFG VEKKVQKKTS
CFGFF
//
