ID I7M390_TETTS Unreviewed; 669 AA.
AC I7M390;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=protein-L-isoaspartate(D-aspartate) O-methyltransferase {ECO:0000256|ARBA:ARBA00011890};
DE EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
GN ORFNames=TTHERM_00580360 {ECO:0000313|EMBL:EAS02693.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS02693.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
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DR EMBL; GG662527; EAS02693.2; -; Genomic_DNA.
DR RefSeq; XP_001022938.2; XM_001022938.2.
DR AlphaFoldDB; I7M390; -.
DR STRING; 312017.I7M390; -.
DR GeneID; 7826645; -.
DR KEGG; tet:TTHERM_00580360; -.
DR eggNOG; KOG0061; Eukaryota.
DR eggNOG; KOG1661; Eukaryota.
DR InParanoid; I7M390; -.
DR OrthoDB; 303909at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF0; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR Pfam; PF01135; PCMT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01279; PCMT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..111
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 77711 MW; FC3FE6CB0489AC23 CRC64;
MENTGSESNL LNSQVKQKLS DQITDDSCTR FDENSMSSEN RRDSVQSSSK RIRKLSMEEV
DLLKKYRKGR EKNVIKVRQM RKNTQNLREN FKAIKENMIE YLEKIDSLID ERCEEIESKV
NQLESDCIIP EIEDIRNNYD SQKSKDEDHF NQELLESNVN DQHLEIISKL IECKRNVSGD
FDSTQNHKAN VLSEYIQQLN QCISHLHEYI DEDQSQLLKS LKCIQNINYL KLLQKLREKN
YIKSDLVESI MLQVERSDFT TNPYEDRAQQ IGFSTTISAP HMHAYTLEIL KEHAQESMKC
LDIGIGSGWM TTALAKLMKD ESAICYGLDH LQGVLNISKK NIMKNHKELL ESGKIVLVKG
DGREGLEDYA PFDIIHLGAA ATLKAVNKFI HQLAPNGILV GPIIKDTYSQ EFMIIRKNAE
GQISKHTLLH VTYGSLVAVE EQYQGSDEEE YYENAEDQIT FQQQVIHVEK KPECELEDEE
NLFQDLSDNE DEDEDEEANI GTSNFFRSIL STGRTDSLLN RLNNYQHVLR NIFSPSNFNY
LNRDPQQEPH PQQQQQQQQQ QQPQQQQEEH ENSENQQQEQ AQQQHQENQN QMEINEQQFN
ENQNRQNQAN NQHEISTSNT VNNENIFQSG SHEGITQEED HTQLDQQKQQ DNQNLNGNNE
NNEIDENQV
//
