ID I7M649_TETTS Unreviewed; 1749 AA.
AC I7M649;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Bromodomain protein {ECO:0000313|EMBL:EAR84277.2};
GN ORFNames=TTHERM_00715810 {ECO:0000313|EMBL:EAR84277.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84277.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662447; EAR84277.2; -; Genomic_DNA.
DR RefSeq; XP_001031940.2; XM_001031940.2.
DR STRING; 312017.I7M649; -.
DR GeneID; 7831852; -.
DR KEGG; tet:TTHERM_00715810; -.
DR InParanoid; I7M649; -.
DR OrthoDB; 276851at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR CDD; cd04369; Bromodomain; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR PANTHER; PTHR15398; BROMODOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR15398:SF4; BROMODOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 34..99
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 238..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 273..307
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 382..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1329..1343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1749 AA; 199996 MW; 3A7A3537EEEAE443 CRC64;
MSKKIVKGGG SNTAIKNTSK PLEESILDII NDISKRQYSL DFREPVDVKA LGLSDYYDIV
KKPMDISTLK NNFLEGVYKT IKEVWEDFDL IVNNCKAYNR IPDHPINQKA DQMKSRVDKN
FQKLLEDYKA LGVDTDGYQI QIDLDDLKAK EEKKRKIKLD GLDEKNILIG GDKRLNLIPG
SLNERKFFEL SNQELQMMQA GKNIQMLPLN QPLQQEDPVF QPTSLKISLN APNLSLNLSN
STITGEQPTP TNNQVGMKQP RITGDNTQKV KKQKDYSAKI QELQTLLAQL KLELEVQTKK
KSDVEKQRIL CKNVYILSKK QRRGVHQLVQ QFETEENTLI NPEGTLNNFS TQSNLNGSEH
INAQDINDAA TSGTSLKTPQ KREDNGNLDD QTAKKMEIEN KEIQKSQDQE GRYNDDDDDD
NDIIIKKKSN FIDDLSLKQN ESTSQIGSNK IKIPTSQTLN KEANSSTQLN DSKISLKQSQ
IGQKSNNDSF STPTKQQLLN SSNLSSEKIK QSSKTNNLNA SESKFQSNTN DGEESEEEFV
PQSLNTSKQT PSDSLATPQQ TNSIKLHGLK PTSSTANSAH LKHKLHASAS GDKIQIKKPT
DLNSSLRKEG VTPEKILSQA KKDFTPEKSG SSGKQLANQQ AKQLGNGNNP QKVRPNGHLN
GQTNSQSNLS PQSQELKKKL NANTPTKSAL SQGKSTMSGN VLQKKNPSSD SIIKVKIGGE
SIQKSVQDLN ANKIKRPEDE IKIKLKDSTF KTAEKDGEER KVNKITIPNP QAAGGNFLPT
PELKQSQSLK AAQIIQMGQE KKNREMEEKQ KTEEQKRLEE LKKRQNRLKK KEQMLLQAHQ
QKQAEAAAAA AAAALANNEV SDKPVNTSEP PKIILMKSQS LKPEEGASTG SNLIKIPFDA
SLAKMSSTQS QPNSQLDIGY NSRQIYDKII PSKPKKTQSI QQEQNANTSN SQNLNFNKIK
INVGGSPVMP PANNPSIQNF PIPQISVGGE RVDFKFVLDR KALKKEYENM IKRKQLKYKK
LLELNLTKMQ KVTNWMIREW AKQKKDVRSE TLDYFRDILN ERQKIKDNLD IRKIQLFLKM
FLYRLRDFYK DLKPDYIDKL KNISEKLYRI GSRAIVYKTP LSIRDNPKNA SLDTQVSNNQ
ILDESHPLKK LQEEILEIER EMKLFRRMLS RDIQKYQEPD ATTQKSKKSK NKDDGSQYNG
GNDNDQQGGY MNGGQGYDDS KDAIYGMGDK DQQQKQSEIL SFFLEYNKSF EKHSSNLQKI
QHFLAYQNYS NILNQLQSKN PIKSDQLFDI CETFVEDENN NQVEILQYFK KKRKISEHTS
SESMTNNNND TKIEEEGKQK QNDQEIDELN SNIFDNVTLS FNFNLDSKKE DEEGKENTFI
SKSQDNSFNN PKQAINVFSQ FDDDEDDSTE AIMEERKYQE FKSKINQKNL KECNSGSDIL
GKNISDINIS NVINPEFDYF GVKKLNQMIN NKVINKKFCQ NINSFIKQKF QIVEINKIKC
KNAIIYQKMK TNDDLVKNLY QKQQLLEPKI NIKIAPPFLD DLNINCLQTL INLQIQVELR
LENEQNPKSQ MDIENSQNNQ AEKSLEFHIQ NNVNYACCAY FTELPNIKDE IQLNCKENAD
FYSILCQEDV EQVVQSFKIQ KQLYRLLSQD SFLTQEVINS EAVCITKQRL RQIDPQNNKF
LLEISLWTPT DNLGYLSIKL NNEEIFSPLN FIQKIKKFQQ YQIQQKQIQQ QQQQQLQQQQ
KKYIQNQSQ
//
