ID I7M661_TETTS Unreviewed; 488 AA.
AC I7M661;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=DNA polymerase epsilon subunit B {ECO:0000313|EMBL:EAR84419.1};
GN ORFNames=TTHERM_00691170 {ECO:0000313|EMBL:EAR84419.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84419.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase delta/II small subunit
CC family. {ECO:0000256|ARBA:ARBA00006035}.
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DR EMBL; GG662490; EAR84419.1; -; Genomic_DNA.
DR RefSeq; XP_001032082.1; XM_001032082.3.
DR AlphaFoldDB; I7M661; -.
DR STRING; 312017.I7M661; -.
DR EnsemblProtists; EAR84419; EAR84419; TTHERM_00691170.
DR GeneID; 7833838; -.
DR KEGG; tet:TTHERM_00691170; -.
DR eggNOG; KOG2732; Eukaryota.
DR HOGENOM; CLU_021763_0_0_1; -.
DR InParanoid; I7M661; -.
DR OMA; HCILIGT; -.
DR OrthoDB; 1604at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0043625; C:delta DNA polymerase complex; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07387; MPP_PolD2_C; 1.
DR Gene3D; 2.40.50.430; -; 1.
DR Gene3D; 3.60.21.50; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR040663; DNA_pol_D_N.
DR InterPro; IPR024826; DNA_pol_delta/II_ssu.
DR InterPro; IPR041863; PolD2_C.
DR PANTHER; PTHR10416; DNA POLYMERASE DELTA SUBUNIT 2; 1.
DR PANTHER; PTHR10416:SF0; DNA POLYMERASE DELTA SUBUNIT 2; 1.
DR Pfam; PF18018; DNA_pol_D_N; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 53..184
FT /note="DNA polymerase delta subunit OB-fold"
FT /evidence="ECO:0000259|Pfam:PF18018"
FT DOMAIN 232..446
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
SQ SEQUENCE 488 AA; 56315 MW; 22AF0DB4A8239748 CRC64;
MEIERPKKAD TIKLLSTYKS SVTGNLVRPD CQGYKNVSEQ FILKDSQKKY DIQYWKTYFK
RLDQIKEYFM SNFSEESIPI CDKILNIKVG EHQVVIATLY KDMKLKPNVL TVSQQRDNYM
ADDDVIYMED QTGRMQLAFN NTQFKSSISK PKTIDVKNLT SGLVVGIRGI QRVAEINVFE
VEEIYCCDLP HQEHILKIPA PLTYGDDSHL ENNNNFHDLS HYIKNYQDHK FILLTSGLNI
DPNVDRYTLI QLKNHLFGLT NLKPLMSRVC RVVMAGNLIE KNKDLDYNLV GSYRMQEQFK
QLYAEIAKKM HDVDKNINEI AGNVCLDIMP GDKDPAQAFL PQQSLNKCYF ASSKSIPTLN
LVSNPYKFEQ ENIQILGVSG QSMLDIKKYS NYSDQDIDIL QSHLLWRHIS PTSPDTLQCF
PFHESDPFIL DELPHVYFSG NSPKFETKMV YEENTKKRCR LICVPALSAS NSFVIMNLAN
LDTFEIKL
//
