ID I7M682_TETTS Unreviewed; 1342 AA.
AC I7M682;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Translation initiation factor, putative {ECO:0000313|EMBL:EAR84624.2};
GN ORFNames=TTHERM_00648930 {ECO:0000313|EMBL:EAR84624.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84624.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662698; EAR84624.2; -; Genomic_DNA.
DR RefSeq; XP_001032287.2; XM_001032287.2.
DR GeneID; 7840227; -.
DR KEGG; tet:TTHERM_00648930; -.
DR eggNOG; KOG1839; Eukaryota.
DR InParanoid; I7M682; -.
DR OrthoDB; 927222at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR GO; GO:0006996; P:organelle organization; IEA:InterPro.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 3.30.2280.10; Hypothetical protein (hspc210); 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12601:SF6; CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR12601; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR Pfam; PF13424; TPR_12; 2.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF103107; Hypothetical protein c14orf129, hspc210; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51823; CLU; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000313|EMBL:EAR84624.2};
KW Protein biosynthesis {ECO:0000313|EMBL:EAR84624.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 333..583
FT /note="Clu"
FT /evidence="ECO:0000259|PROSITE:PS51823"
FT REGION 123..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1342 AA; 154383 MW; 75D1EA625161ED98 CRC64;
MSSAEQQLQQ NIEEACTAVE TTAASIKVSL HLQGKYLLPL EIAPSDTLLE IRQFLSDSTV
LYFFSNYHFV YQNQKLNEYV EFSTYNIQND EVLEIKFDPF DEKTAKLHVK NVKEALANPQ
TLSNIFSNGE AAEQKQKNKR DSSDDDEEEE DKEENTTEQK ANKNENKQKE KQESQQTSEQ
KNKEQYSLND ALQPSLSNKF ITKELNPKKV EFIECISYIN YSGFNPPPHY RKIQGDFFYL
SVKTLENMSY HITASPQGFF VNKSNSKDFD PEPVNKNVKF VNLVELFQQI SPLFKQNLLK
MVQSETSSDE LNMPLLSFYK YGNKWLTAKN NASEHEWNMN RCENSLINLY GFDVSGPRDW
NEELQICRDL PKSDFIQRLN RDKANIKIQS EFIEAAIEGA KAVVEGNISA LNPMDPPHQQ
VYVYNQIFFS FALENTDHFK QETGPDASPN VTTANCDLRN LKILHKLDIP GLSVLNTCLV
DYKGHRVIAQ SIIPGILNSD HSNCSQYGSI DDGKTICNNP EFEEIMKKIC EHFHLDDEVK
FYDENKKEYT LCGSIEVKGI RGSDRRKYIL DLMRLSPRDV NYSGNSDNLC CTLRNELISN
YVLSKNFEAA NNQLKLQEQE EMNNKTESTE QTTEEKNKKG LSKFLKMQEY MQNPENQIKL
KLNSNISTKA PLVEVPKLKD QFNQLQEIGE YLMNKAIPNV INDLISNSEN GRISDSRSIE
EFFHIHGVNM RYLGKVLNKI SKKDSPHIYL ILERVILVKA MKHAFREIMR NTASPYLIQA
LTHALNCIFS SPEVREKLEK GEIKSTESNL VNGDNNSESK KKKKGKKGKK TTSNAQSEKI
HETLNSIETC QELGGIELAL PEFLSSKPSD LWKRIIHIAS KRYEYKLPEN INDYTPLNLK
FNRLATLRDL CLTIGVHIEA KDYEFTFESV VSNLNEKPAN SSQSSQSTNQ NSVSSNNAAN
TNSSKSTLPF QPENIKNITP IVKYIEINSD DSRANLEMGQ KYLIEGKANE ALECFHTAAH
IILNLFGPIH KDYAYCFYKI SNIYFKLGDY ENAIHYQKQT IQVFKKLYGI DHHQTAQAIS
TLAYYYFSIK KYSLAYKNMF KSLFIYSLIG GEPHPDSFHT FMNLSLMFQE NEQHQASLSC
LFEALDRSIT VYGKDHIKIA GCYQAVALAH YDIDDIKKAI EYQQKCVAIL KLNLDAEDPR
VKEALLFQHK FEKTLADKKK GQTTQPIKDV NNMRQFGTNK TVKPKAQEKI EDQQFQEQQQ
INEREILKQK LKYAKMNAKY GTSARKPYPY DINRIAAAEQ ENLELQEQTQ SENNKKQQPE
QQQLNGKQSQ QQQQQQQQAK KK
//
