ID I7M8U4_TETTS Unreviewed; 504 AA.
AC I7M8U4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Pre-mRNA cleavage complex II protein Clp1, putative {ECO:0000313|EMBL:EAR99683.2};
GN ORFNames=TTHERM_00590200 {ECO:0000313|EMBL:EAR99683.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR99683.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662637; EAR99683.2; -; Genomic_DNA.
DR RefSeq; XP_001019928.2; XM_001019928.2.
DR AlphaFoldDB; I7M8U4; -.
DR STRING; 312017.I7M8U4; -.
DR GeneID; 7831830; -.
DR KEGG; tet:TTHERM_00590200; -.
DR eggNOG; KOG2749; Eukaryota.
DR InParanoid; I7M8U4; -.
DR OrthoDB; 56092at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 2.60.120.1030; Clp1, DNA binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF6; POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 18..110
FT /note="Clp1 N-terminal beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF16573"
FT DOMAIN 124..218
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT DOMAIN 273..370
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT REGION 230..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 57966 MW; 81ED285C9BA50FD2 CRC64;
MMEEQFICDE KKFIRQEVEK MREFSFNINN EDGLKLFLKE GTAEIFGREL PQYTIQQFQK
GDRFSIFTWT GCVLYLEYMS HSDFFQSTDE SQYPIYANIN QYLHEMRSQA QDQRKIGPKI
LICGPNQSGK TTVSKTLTNY CCKLGWTPIL VDLDPMLNTV MAGGCIGACV CKDSYPTNGI
EIKNKIIFFH GYSRIQLGLL KNQIEVLGNT VQKKLQNNLE QFLKKHNLQT APDAEGAQQK
TNKQKYPSQQ NIQNSTAQIK LPSGVNINQM LLLPQDKQMF SSGCIINMPP LQSREQKEVI
DLIIKHFQVD VIIGLDDQVF NSLKQNQLLT NGYSVIRTTK PSGLKTKEES ELVEEARKIN
QKLFQQYFKG LNNDIDCHNQ EVNLNDLLVY RLKINEKNSL ANTSMQQQKQ IYERVDLSKE
NVTKSIVGVL NLTRSSVEKL KEEEIFEKIS KSTLSLLVHL SDMRTNQPYV RLFLPGLNME
NIIKENVCVI GDITWFESSS DKKK
//
