ID I7M9Y9_TETTS Unreviewed; 444 AA.
AC I7M9Y9;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Ubiquitin-like modifier-activating enzyme 5 {ECO:0000256|ARBA:ARBA00016279};
GN ORFNames=TTHERM_00444560 {ECO:0000313|EMBL:EAS03074.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS03074.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC subfamily. {ECO:0000256|ARBA:ARBA00005339}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662504; EAS03074.1; -; Genomic_DNA.
DR RefSeq; XP_001023319.1; XM_001023319.3.
DR AlphaFoldDB; I7M9Y9; -.
DR STRING; 312017.I7M9Y9; -.
DR EnsemblProtists; EAS03074; EAS03074; TTHERM_00444560.
DR GeneID; 7826949; -.
DR KEGG; tet:TTHERM_00444560; -.
DR eggNOG; KOG2017; Eukaryota.
DR HOGENOM; CLU_617512_0_0_1; -.
DR InParanoid; I7M9Y9; -.
DR OMA; ITINAYE; -.
DR OrthoDB; 180391at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF9; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 29..164
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 444 AA; 51158 MW; 8E44872740055F94 CRC64;
MDIESNKIQD NSQSKNDYFK RQKTIPGWNQ EIVSNTTALV LGAGGLGSCV SIQLMRLGIK
KLILVDYDVV DYHNLNRQIM FTINDIGKSK VESAKQNLQF HNISNTEIET HNINAVTQWE
QIVALAKQSN LVFNLIDYGD YFDLAVCSLC IKLSLPMFQG GTFCNSLSVD YFTSDGRPCL
LCLTDGLKKE FIEKLNPSLI LEYKSLEFLP KNDNPEGQSN IVICQMCANF INTFVLNELF
PSGQKKSKRI LLYLDPIDII SFDLEITPKC PYCREPFHEG NSFHEVQSEE IPLSKEDLWK
DIKNLQLQKL FPQYVQEIQV IEGSLGQIDS KLQITYKDGA KWTVQLVEIS SIKQTIVYDV
IQTQPQFSCK KFRNIFQISQ PDNQNALNTC ELLWRTEFQD DITINAYEDT KYKKYDYFKN
LIETIITNSK NEEDQNKQQK QQQS
//
