ID I7MB12_TETTS Unreviewed; 324 AA.
AC I7MB12;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Papain family cysteine protease {ECO:0000313|EMBL:EAS07100.1};
GN ORFNames=TTHERM_00683060 {ECO:0000313|EMBL:EAS07100.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS07100.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; GG662247; EAS07100.1; -; Genomic_DNA.
DR RefSeq; XP_001027342.1; XM_001027342.3.
DR AlphaFoldDB; I7MB12; -.
DR STRING; 312017.I7MB12; -.
DR MEROPS; C01.A54; -.
DR EnsemblProtists; EAS07100; EAS07100; TTHERM_00683060.
DR GeneID; 7824746; -.
DR KEGG; tet:TTHERM_00683060; -.
DR eggNOG; KOG1543; Eukaryota.
DR HOGENOM; CLU_012184_1_0_1; -.
DR InParanoid; I7MB12; -.
DR OMA; MTHAEYL; -.
DR OrthoDB; 808912at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF953; CYSTEINE PROTEINASES SUPERFAMILY PROTEIN; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000313|EMBL:EAS07100.1};
KW Protease {ECO:0000313|EMBL:EAS07100.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 46..96
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 118..323
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 324 AA; 35902 MW; 1C3073E1E475B1B4 CRC64;
MSQKITVTLV AIAAIAAITA AGIYYQNHQA SQLEKSFKRN TILEQWNEFK QKFGKKYADQ
EFERYRIGVF AQNLEVIKND PSFGVTKFMD MTPQEFEQSY LSLQLQQNFN AEKVDGDFNG
DIDWTQKGAV TPVKDQGSCG SCWAFSAIGA VESALILNGE DKNINLAEQE LVDCATTPKY
ENEGCNGGWM DSAFDYIIDE KISQTKDYKY TARDGKCKDT SSFEKKSISG YKDIPQGDCK
SLLNALSQQP VAIAVDASSW QFYNKGVLSS CGSRLNHGVL LTGYVNETYK VKNSWGTSWG
EKGFIQLKSG NSCGLCNAAS YPLA
//
