ID I7MB64_TETTS Unreviewed; 812 AA.
AC I7MB64;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=RNA-binding motif protein {ECO:0000313|EMBL:EAS07732.1};
GN ORFNames=TTHERM_00497860 {ECO:0000313|EMBL:EAS07732.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS07732.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GG662212; EAS07732.1; -; Genomic_DNA.
DR RefSeq; XP_001027974.1; XM_001027974.2.
DR AlphaFoldDB; I7MB64; -.
DR STRING; 312017.I7MB64; -.
DR EnsemblProtists; EAS07732; EAS07732; TTHERM_00497860.
DR GeneID; 7835343; -.
DR KEGG; tet:TTHERM_00497860; -.
DR eggNOG; KOG0154; Eukaryota.
DR HOGENOM; CLU_347655_0_0_1; -.
DR InParanoid; I7MB64; -.
DR OMA; KEKECAG; -.
DR OrthoDB; 180604at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR13948:SF3; FI21118P1; 1.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 342..371
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 400..480
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..26
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 93793 MW; 9E7EA2B03D9C75F1 CRC64;
MSDRRKGKRS YSRSRSRSRS RSRNKKHSKN STTDYHRSSQ NSSNTHSNNG GGSNNSRRNT
ESSSYQSSSK NNNSSSGNSR NDSNYSSSNY QASNSSSSMN KDSKSSKESK DSRDHRDSKD
NRDYRDNKDS RDFKDNREKD HRDSRDYKDH RSRKDSRDRD RDREREKERE NKSSSNKDAK
KHSSSQNKKE SSYSRSRSHS RHRSSRSSSS SDEKKKQKSL EKLQSSSQQW NFKAKYDESK
WLMIENIPDT IEKKDIEEKL TQVSADCGTS IYDDVRLVQY LGSAYIQYPS VSAASKTLYH
LKGKVKLRDQ FYPIDFYNTT SSSNGSGSGG NQSKAATLYD NIQADWICDK CDYKNFAKRV
KCNKCEKPRS SSCRLIMSSV SGVKPSLGSS SGAQGELTTS LMIRGNVVST ISESHLIDAF
EKYAKIKDVR LVKNKQTLQQ KDFAFVEFYT IEDAEMVLAQ TNVPEFRVAG EPVTVLISRN
KKAEDTSASY PMVAATTYDY HQQQYGAQYD YSQYYQQMYS QYGQQPAYID YDAVGYTAYD
QQQQQLQQVY QQQQEQILPA SPYKQVQQSQ LQASIPNQIQ LNTVQQQLPQ QQVAPQMQFD
VTYETFDQSD LIKQALENVK NHSLSLQQQK EEEKQKQESL RIQQHQEEQK KKEQAEKNIQ
AQKTMEDQIK LLEEQKKALK KSEDENKMKE VQNKIKEKQD EQQRQKQRLE KLKEVSQKDE
VSIEKQQDSQ KSGEDNKMNF IQFETNAFST SSMPLKTIDI QLNGLNSSSQ KQKEKIYICS
ICKSKFESEK AVNIHNTHSK LHKENLKLYG LI
//
