ID I7MCN2_TETTS Unreviewed; 2093 AA.
AC I7MCN2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=REJ domain protein {ECO:0000313|EMBL:EAR84416.3};
GN ORFNames=TTHERM_00691140 {ECO:0000313|EMBL:EAR84416.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84416.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662490; EAR84416.3; -; Genomic_DNA.
DR RefSeq; XP_001032079.3; XM_001032079.3.
DR GeneID; 7833835; -.
DR KEGG; tet:TTHERM_00691140; -.
DR eggNOG; KOG3525; Eukaryota.
DR InParanoid; I7MCN2; -.
DR OrthoDB; 201645at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002859; PKD/REJ-like.
DR PANTHER; PTHR15332:SF175; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE; 1.
DR PANTHER; PTHR15332; UNCHARACTERIZED; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00261; FU; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..2093
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003712137"
FT TRANSMEM 1974..1998
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2010..2028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2040..2061
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2073..2092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 945..1334
FT /note="PKD/REJ-like"
FT /evidence="ECO:0000259|Pfam:PF02010"
SQ SEQUENCE 2093 AA; 240176 MW; 63BF2E6B9F7DF71B CRC64;
MFKKEEIKKN NLLQKFFYLL LMISLVEALH IDLLNEQQPF FYTKKNLNNP TQTPFCTSKN
YITASSDTIE INFPYSKIPL FNRVTYAIYM RSMQNIKSTL QSISDGETIT TKLSTNLNNE
CTRQNDGIQY EFPNYYSGVS QFFKNYSNQF TVKIYEPNLA SAFIYQFEIW IDQFQCQEGC
YQCIDNHNCQ PSGCLSGFTF MYLTIEQHTD ICNRNCPQGQ YANLIQINYL IQECHDCIPN
CLICSYTIRC IQCADGYYYN SMTKWCDVAI CTEGCSNCSQ NKQSCTQCIN GYTQKEKPND
STLQYCQKNC SVGQYNFVTN YTTMSQECRS CIANCQTCTK SDDCSNCQTG YGYNSQKQQC
AQCYQGCSNC DQNLSCTQCI SGYTQTANPN NNSQQYCKMI CPVGQFTFID WQTMAQQCNS
CITNCTQCSQ DKQCDTCIAN YEFIQQVYQC KVKCQQNQYR DQTFYDCTNC VSNCLKCIDG
QSCGQCQSNY EYVKEVNTCL VICNQNQYRN PQNNYLCADC IDNCVSCTNG QSCTTCTQDH
EYVSQVNKCM QICSQNQFRD STQNYLCKNC HLSCQSCTGP AQSQCSSCYQ GWYQLGTYCY
QWCPNNYKEN SILWQCLQCQ EYIKPDCQAC ANTCRSCQYK QSSICLDCYE SMEMSDKTCV
CKNHIDNRGI FYECSYNQIA VLQATLAVDS PTLIIDFGVA LTQIQNFQCN NIFQDSTLQL
LGTLPNCSIK DTQIIVQLSQ DAQIMENDNL SFISNVLSYQ ISNTFFIDTF YLTEVKQLRS
DTQQPQVTIQ FSKIQNNCYD IVFSVADIIN DAQRGFKSFT WSIKSSPSLD ENSLETVNSI
VSNANSQKSI SLVIQKHLIP ANTKITAIFQ YLLKVNSSQN QQFETLFIRQ KDLVINFETQ
SYPIYRFMDL RVYISFYVQI CDQRGPTITN EPLNIHINSK SVPKLNQNLT QFKYNQTLVL
VEKYSIPQKI VFDLNVNASL VSDQQIANLK TQTITPNISD LFIQIIGGQQ GIFGFKKPLN
LTGLARDFEL EDQDQDQQIN LKWDCVSLTS NQNDNKCYDY NNHLIVLQQN VPTISIPGST
FSPYQTLLFT FTGIKDSRQK FQSTMVFLSE TDIPILIVKF QDYSQLIQVN INQDIDATLI
YGSNVSSDLL SYAGAILYNN TVVGAIKFDY YQVRFRIWDY FVNILPSNAI VQVRFSAYNP
YYIMPSLSIN NFNINLPPKN CVLSINSPSG QALQTIFQIK MSGCFSANAP ISYQFFYYLN
DTDYQQEQVS PNYILRRQIM DQSLQNELST ILPSGNLTLM VQAIDCYLAV YNTTIQVNIQ
PFAQNENQIN SIIDQALQID SSKTISQNVL NLCVIGEEIS KNYPVYNLQS INTQKSQLIQ
LIISQVNSLP NSSLLSTYAN KVIAQLQQSI SNQQESQIIP VLIQLNTILQ NQQSLISQND
MFMNNNNVFL QNVVDSFKML NSTTQILSNN LISQQMNISD QICSYLSKAT LPNQGGVQLQ
GNLISLDCQQ ITSKNLKQVM FDYQDSRTTN AYYLGQTTYS QNPFEQTSEF QNYIKKLKQV
NSSITITQNP VIKYSLDLAN TSSNRLLYQQ GSNFLQMSKM PTNRKLINTK ENQKDNQQNV
YIFKFQDLQP SPNNQTCLQM QQSQAWSTNG CNNVKKNNKY YCYCNSTNPT TVTDDLESLL
INKNVKEAFS SDGFNNITNF DKFYQYALVW TLFTLTLLQL GLYKYGRNLD KKFSKTTISQ
IMPMVSEQEN PPISQKNQTP SLQLQSIQEL NGVIQQTNQD QQDLINSNNQ TTRKRQKFIN
TLTILKNEKI ESKQMDLLKL ENQISSTEQP NFMKNLDNQV LQLEEQVQSD QIQEFKQPKI
QDENLNQGQL IDFQEVQQDK LINSNKVTVS TFQQQSSKSN LANEDVKLKE DEIQTIEQLK
KLSLFVQFKV FHAYFNTIYT YEPSLSRPIR FNIIYLRVVH SLCLSTVFDE SYNVIQKIII
SIVSSIIVEV GVFLITIAHK ITRIGQKLST FFMVCLLLFY IYVILAVISN EEPSYANSKY
VQFFLVIGVD FIFFQSILAL FKIIILKNIQ KNIIFYKFYA IFGLSKVVSS LTI
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