ID I7MCU5_TETTS Unreviewed; 1249 AA.
AC I7MCU5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=TTHERM_00585050 {ECO:0000313|EMBL:EAR84948.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84948.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662510; EAR84948.2; -; Genomic_DNA.
DR RefSeq; XP_001032611.2; XM_001032611.2.
DR AlphaFoldDB; I7MCU5; -.
DR STRING; 312017.I7MCU5; -.
DR GeneID; 7823749; -.
DR KEGG; tet:TTHERM_00585050; -.
DR eggNOG; KOG0519; Eukaryota.
DR InParanoid; I7MCU5; -.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43719:SF28; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK2; 1.
DR PANTHER; PTHR43719; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:EAR84948.2};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transferase {ECO:0000313|EMBL:EAR84948.2}.
FT DOMAIN 474..727
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1117..1244
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT COILED 411..438
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 1174
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1249 AA; 143464 MW; DE685C761BB7A49D CRC64;
MDKATANKKM QKTIKVQMKK IHCLLNNTSL IESNQLHYTN ITPHSFIGYE KKSYNKILNL
IEEVSDNISL GVAIFNSYKE LIYTNNTITQ HFIKVNTQKT SIKQQLLLYS LDNKNVSSLA
LKVNSQKQSK IDGGINRSTT MGPSIRLIQN SSQVIKQFIN SNYYENYEFQ HGQSDKLKKS
LADLEDKNLN KNSSKKKTTF TLSNENFEQQ KTNSIFYQDT DIRRSNLLTS NKSIFVKGSS
LSKVNLNKNN KIREKLNSGL CTLGELVQII TDLNNYRNEN IYKSAQVLQH PSKLQPFAFK
RGKSQEDIYQ NENSRQSIQQ SKHDNTSNLN AADCINSYQS FQQTDNFMIT KIDYHIQANE
VIVTTKNKQN EKILIKFKAY YIKEQQSTTN TSNLNQPNIE ISSYNNNQFD EINSEQNIQD
EEQEYEESKQ QQQLTSSNII VIVEFIKNIL FGYDLDNEDT KDEINNYKKK ILSSVSHELK
TPLNCSIQLL DLLYQSDTID EIQKKMFIEP ALNSNQLLLC MINDILDFAL IEKGELKLTF
KSFSIIDLIR ECISYFIIQA ASKEIQIELN FDQNIPQIIH SDEMRVKQVV ISLLSNAIKF
TQYGSISINV DCILLHNPPQ AATEIIKVTV SDTGCGIEQQ VLKNIFDGLK YRQDSPQQSY
NFYMDSTKKR SISNSKEQQR KLNTEGVGLG LTIANNIAKG LGGNRKIEVQ SQLGKGSTFS
FYIVNRSQKS KGCEINNYKF MSQSFSQWRS FQSKEISEQI SLNDNYNSSY NKSEDISNHA
YSNGIITNNL NCKQINHRIS LSVSCNNIEN SNKNLDFNEI QVEINDSQQI QAKSPFKVNK
PRNLFFQNQQ LSGKFLNTNE TLQQSINNQL IQEDSCEIMS DMNSHKHISI PNQPIIPTFF
SHYYQSSLLQ NNNTDLSLKS LAEGQFSQQD CYPQNSNNQV RIKDLELQQM QNNFQIFLKN
TRTSFSIQKI NQNSMDLTNY AENLKLNNQG SQYKQDCNNA TNNLKINKTN YQQSITSLKQ
IGGISCKVIP SQNSNQNLQR APKNSSISNL DQNIYNNNIN NNNFIENNNQ KSIQIDLNNG
NNNNNNKPIK KEDTQQMKNV KSLLKEKNQK KTCGCSNILI VDDNQFNLHA LQLKLKNYDF
IIEVANSGIE AISKVQEKFE KSNCCKQHRL IFMDIDMPIK NGYQTTKEII NFYNNQKVKP
TIISACTAYI QESEVKQAKE SGMKYYITKP VATEQLEEVL FKVFLQKKL
//
