ID I7MDA3_TETTS Unreviewed; 919 AA.
AC I7MDA3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Transmembrane protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TTHERM_00548090 {ECO:0000313|EMBL:EAR86070.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR86070.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662864; EAR86070.2; -; Genomic_DNA.
DR RefSeq; XP_976665.2; XM_971572.2.
DR AlphaFoldDB; I7MDA3; -.
DR GeneID; 7822824; -.
DR KEGG; tet:TTHERM_00548090; -.
DR InParanoid; I7MDA3; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR045203; RanGAP1/2.
DR PANTHER; PTHR46761; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR46761:SF2; RAN GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF13516; LRR_6; 5.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT REGION 494..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 612..639
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 919 AA; 104174 MW; 2E37CD9D86B2AB39 CRC64;
MFKKLMQSTF KKVSDPKLTS QFMKYNFTQP NNHIKQKQSS LIPVQNKSFK VCEIDYQVDD
TPKQSVADTS DQYCKETSEQ KVIDEQSQTT VNQVETKTAS TTTANTNSSN ITTNNTTANT
AQLSQVEKSK VHEIKYYEEL EEFLNSSLQS HQVLHINLSN QFYDDKRLQD LFSALANCTN
LTNLTLRLGL YYVSLLGEFE AFRGIGAVGI SSLGSALANC TKLTNLTLVL DGNQIGDEGA
SSLGSALEKC TNLTNLTLSL QYNKIGDQGA SSLSSAFKNC TNLLNLSLKL TLNQIGDIGV
LGLASALGNC INLSDLELIL EDNKIGAVGA SGLSSALANC TNLSNLKLNL NSNTIGDEGA
SSLCSLLTNC TNLSNLALTL YDNQIGAVGA SGIGFGLGNC TNLSNLRLNL YKNQIGDEGA
SDLGSGLGNC TNLSNVDISL KQKHREFTIG AFLDQQAEKN LSACYFFAFQ VFSLEGYFFI
LFKKHFQQIF NKGQKTGQKT GQKTEQKTEQ IRQKTQQDQN QFGINTIKDY EEQSERETKK
QKALKQNMQD IQKLSGRVEF IEWIQQKNIK FMIAQFKFFT NEKFNRKQEA KEILKKLCKS
NHSLQSTQKL DLDLVSQEVE NTEKTIAELI DKLKKGKEIQ GEKELNQEYT KYFGLKNKLM
FEFISRYFVM FGKQINQCHD YFGYSCDETN QYLRQYVFCL IERLQFVFCY LNDTIQIDTR
FKVAHDFDQE EFQIPQNWQV QKDYRKIYYQ IIFTINFQEE KEIPKQKSNV DKSVVDKSVV
DGSDVEESKE QVSEAENIPT DQIPVTEIPI ETSNVEESKN DEKYVFSQPN TMCLLLTDDL
KFKESLEDYK IQDHLSNELK TILQNNDVEF SPFKGKEKVE INSLYDNEGN LVIRYTTEDF
IMKHTVIISE SAEKQLKKK
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