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Database: UniProt
Entry: I7MDI4_TETTS
LinkDB: I7MDI4_TETTS
Original site: I7MDI4_TETTS 
ID   I7MDI4_TETTS            Unreviewed;      3380 AA.
AC   I7MDI4;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=MIR domain protein {ECO:0000313|EMBL:EAR87665.2};
GN   ORFNames=TTHERM_00538860 {ECO:0000313|EMBL:EAR87665.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR87665.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662849; EAR87665.2; -; Genomic_DNA.
DR   RefSeq; XP_001007910.2; XM_001007910.2.
DR   GeneID; 7839131; -.
DR   KEGG; tet:TTHERM_00538860; -.
DR   InParanoid; I7MDI4; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3031   3049       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3070   3089       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3129   3156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3177   3199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3261   3284       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      215    419       Ins145_P3_rec. {ECO:0000259|Pfam:
FT                                PF08709}.
FT   DOMAIN     2552   2675       RIH_assoc. {ECO:0000259|Pfam:PF08454}.
FT   COILED     2011   2034       {ECO:0000256|SAM:Coils}.
FT   COILED     2244   2264       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3380 AA;  396378 MW;  944452ED42D5D19C CRC64;
     MDETSQSIGW MYRTQIESGF KQLDYLLKRY YVKSLFSGQD QYEENKQEEN ELQTQKIQST
     IKEEVYNDSK NISDQIKTPR GLGNTETKSP QNIQSQFSYK TSKLSSIQPQ LIQNYINEQQ
     SDMMDQIIDE PPEVIQVVEN QKNITKSLSK FRQLNLDSVQ SQQSPNIFVN NYNNQEIKEL
     QSTEKAFKTL QFNDIVYLKF KHESKKETNS EELKSFLVIT NTRNQLECIS EQVESLDNPI
     ANFRRCLFQV LNPRQALEIK KHNQYNAVQK KVQRQSLLSL ELSNQDENNF QRNKKLQMFE
     QQLNVKNDTH EDDGDLLVYG KQVMLYHQYS KMFLTFNPQK PAKKNGCIQC TLEKFPNQFS
     IFRMLPNDYS RRVGDKIFDS DVINIQEIKN SQFFLNVSLT NKMIKDPQQG NIGFLQNNVS
     IQPSPFRGRQ QNRIHINASE EQTKFKVKCY ISRESLEQTK DQAEEGIAFK TGDIIKIQHL
     DSGAFLSVSE KKLSRFILTK NCRIQHSHDE VYSGLSDQIF TLRFLDQNKV SSPENFEAIY
     DSENTNSSYS FWEIQRKDHF TGGDLYSEEC FRLKNLATGL FLSRDKGMPT KFSLIWNGKD
     QDCYFYVKKD KTNNEKKKIY LQDTFKIYNQ ERKYIHVASN PEKGKITLSL QPKISGVSLP
     YLHAFTTTDK KVVDFLEQSL QIYNTLLQFH YFLQCFAIND KLKGNEETVY SYQEAVHQQK
     KLESEYQYVL RALNELEILL MKESVDSLQV FQMKQQFLRE QKVLELLILI VKLIDVMSHG
     NRSQQGQKDK SKLIKMNRSV GYKINEKSPQ YIVNKHLCQL PVKIFNILYL GSKQNANWSS
     YIFENDDFFS GQLRYYPKEV GSLLKEAIKN LFNLKGEGAQ GDEIVEWVKL LEPLDESKSN
     ILDQTFYIDF ISLAMIDPQQ KPLQIYQNKC STELFSKGKG GQSKAIIQFH QDFTNGTYIS
     FYHETPLNEF INSNAPLNNI GVEINKRDKM AFSLEKMSKD AEKNKSIAPY LNYVSSVLTL
     LANLCNGRNK KSLTQIKNTL GINETHIFNA LKSTDINISI RTSYFQIYEV IFLDDEPFLT
     LEKSQNRSYI WKDIEKRFLS RKTAEIFKQL SDQSDVIKST QNFDQNILPI LEEFWERGMP
     ELEIQALNKY QFNNLTLEQQ QEKQQNAKIL LRFVLVVLQV TRIAMDLGQL TTEKIDQIVN
     QAIQILNAFI NFSKFKSIFQ QEHWLKKFFN KIQNYGDLDQ ELEAIIIEVS NLIRLYLKIK
     QNLQINQLLK QFYQEYTSQK SRKKFRELQE DFQQIIQDFT IVQKQINVPL KENKKRRVDF
     LNFIQQNEGQ SQSIKDSAFN PYGRNNSNSL NANNSNNNMI SQFNADKNEG DKKDNLDDDS
     LANKIENMML TFLLSKEKSN ISLAYDHVAE TMQIAMNHAK FFCEEIQHVE LIDGEDELSL
     YKQLDSNHSE NQIVSPIKLE IQVNNLLFDE FNKAKALKNE NSSAENILQI NNLVDKIVGE
     FKNKRNNSNA VLLNKMQNIL RNVRVHKSIA NLLNLPSDEK VYHNMFECVI SFLIIFCQDN
     HINKKEILPR FDDLLNLINY NVKAQKLIGL TLQSVCQSEL EFKPYLQAIF QKLTSPGITK
     VGQTHIFEML LAFLKKIDTP KFQVIQDTIQ FQKKIKREGI LIPENQSKIL NLILQLNIIQ
     PFLDQHKTPS DFLKHFKEGQ KVKQDIYLYK SIMKLMSALS ENNQLGIIQC QRILVYEDLK
     QLLLSAQSPF IIKKEVFKIL FQIYIQQYED QNNGFALVEM NELLQNVVLK DLSQFSRYIE
     GLVDPNNKYL FEDNKEKGVK LQQKLREFIK DLIEEKSVQS EQKQVLIRKS SNNKEDANID
     IIASPKEYWD YLYSGSNWNF SKDGLLQILL DIYREIDKRK WLAFETSQEN KRGSTDEENL
     TDHLLSIKIM CENIRFILKK IQNKFQIDLT EITYMFSECI ILCSTKKHRT NMSNFKHQSQ
     NLPSISLEKK LKETRTEDLD TYVKSFGQAK LNQINEQLEK HKNLFEKYQL LEQQIKDAPK
     EAINFTNDKV VSSQVASVVH TQKNKASKEE LKNSIITYFL FLEKLRNLIL LKYITIHQVY
     EIFDSNYNPL DQNEEFLKEE LRFINQIENE VQLQPNPFLI NEQEFIAKFV NLMKSVEIFG
     INDQTYIDYD DIYYFFNAFI NIYPFQEVKD KMIQLGAQKE GIQTNIGMQQ ASKSNNQAQK
     MDKQVFLKKL SRYVEKNKSV YVKLQKQKNE LIQLTENEKS FQQLQSLKKY TSIFERISEE
     NCKEKPFKLF AQKIMNEILQ SNDTDQGRKI KLYFEQFVSI LKKKDSHYFR ILQYFIKDLG
     IQQSKSVQQI QNSQKQSTTT LANALEQIGL QSKQSKEQKK QTNPQVYIKI SQNLIWNQKL
     YYQILQTISD IHIEQQQQAA NQNKNTFQSI FQQQAQTASM QQQQQDAFNN MENLHNRFSC
     QVKQYLSKRE QNVSILLDCM EIINGLYHLN LKNSHAQILA ILKKPSNIKI TRNFLSFIKQ
     SFSNYLQAIE NLSNQDAQHY ILYQEKKKDL QNQEEIVLQV LKVIQNSCEL CNEEFQNFFR
     TQNIISSQSY VPLNILNEIL YFMTNFTQLK CSYFNSFDQS SQGINCNIFQ GQNLKYYLVI
     NQCISTLKNL CNGTSPKNKE LLLSNSHFLV QLNAIITESD LDLQSENLKD VRILQTVSNC
     IDLLLTIIVC SNNEKSLLGL ITIMNIEKLI KLLNFVYHYK IKSRLEIIQQ EQICTHKNST
     TCSTSVCYKK CITYHDQLVM RLAFNIVIVI ELILDKVNEE DLNMKMRMQE ESSNLLGILL
     EMKKKEDFFE MEQTKLHSGL SVEAAQQNSQ SVQKVSDKLS QSFGQKKLYK NQKTAKKIST
     KKSTTLHNLI YNEIKDDQSS KQDEIDAFYQ DQLVHDMGVQ REVNPSGKIN YYKKERLYLI
     ESLSFYLQFV GSVEIVQENQ ISKLFFRIPL LSSYLTHNIR KNLIQKAVNY SDKNRLKLLM
     RYSEYFQHEM RFCQNLSKYS LIIQAVEYRN ALNIFIFLLI VAINLIFLFK MQIKPDGSTS
     LSTSQDVIFQ VLKLIHLILT FANMLIVTIE RYPVVTYQKY IELKQNYRNN IISTILRHKL
     VSFIFDFDFI YYLIYLILAI VALDQIVIYS VLLIDIVKLS EDLTQIIKIT KLNLNKLIKT
     TLLCFLIIFI YSLIGAIVFP NHFSDAESFG PVNAAVSTLD FYFFFSTSLL EGILNPQGIN
     EALTIPGVSS NVYWDRFFYD ISFWIIINFL FMDLMLGQII DSYAQFRYFQ RKYEKNIKRK
     CFICSLTVED LEAKTLDWEQ HIKYEHNLNN YLNYIIYIKS KPLDECDGIE KYVKESISKE
     ITDFFPQRTS LSQERLEIKY
//
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