ID I7MEK3_TETTS Unreviewed; 627 AA.
AC I7MEK3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Nucleolar complex-associated protein {ECO:0000313|EMBL:EAR96516.2};
GN ORFNames=TTHERM_00191850 {ECO:0000313|EMBL:EAR96516.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR96516.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797}.
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DR EMBL; GG662693; EAR96516.2; -; Genomic_DNA.
DR RefSeq; XP_001016761.2; XM_001016761.2.
DR AlphaFoldDB; I7MEK3; -.
DR STRING; 312017.I7MEK3; -.
DR GeneID; 7837496; -.
DR KEGG; tet:TTHERM_00191850; -.
DR eggNOG; KOG2153; Eukaryota.
DR InParanoid; I7MEK3; -.
DR OrthoDB; 24935at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; NUCLEOLAR COMPLEX PROTEIN 3; 1.
DR PANTHER; PTHR14428:SF5; NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 45..135
FT /note="Nucleolar complex-associated protein 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07540"
FT DOMAIN 482..580
FT /note="CCAAT-binding factor"
FT /evidence="ECO:0000259|Pfam:PF03914"
FT REGION 293..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 73387 MW; C616723541368754 CRC64;
MGKNKQDKPS KEGETNKSLF HSLLKNERLV IEKKELNSLS LMQLTQLIEE ISQEIIAKPE
ANIIHMQTLF HLLEKDSILI VKLSAYSIVE IFKDITPLYK INFKESQEKL ATKITKEERQ
VIQTECRIYE FYEKYIKLMA YFAKLKNKEA KNLGQEVNEE TKQQFNQLRR IGTKCLLELL
KHLYHFNFAK EIAEFVTHKL VSVDKKVRDS AIEIITSILS DPTHSIYEIK VVILNEMGKI
LNTTTEKDLP DDFIEIVGCV EIDTKFLKKD FDEDKRKKAI EYKKAKRQFY KDKEKEKGNV
KNSKKRKLEN AKGEKDDIDQ VKSMKGVDKN ELKKMKKELR EELEEQDAEI DPKLLIKYNA
QILEKVYYIY FKLIKRPSPT KFFTSVMDGI VKFIHMIDVN LIWDLIGCLQ KSAQNMRQYT
NKKGGDDKMA LHKRMHCIYT VEAILNGPGQ VFDVDDKEAI LNFFHVMIDL NKIPHVFDQL
SQKEELVLIK ILEIMFLKKR QFSYESVASF VKELAKLAIK LNDRKQFQYT VLFVIKMLFS
KHSKINRMLD SDNDGFGLNR YNERIEDPQS TNAINTSIHE ELTKVQTSQN TPEIKNICKK
ILESAPLHPS LSTLSVQDFY NKHSNLK
//
