ID I7MGJ4_TETTS Unreviewed; 378 AA.
AC I7MGJ4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=KOW motif protein {ECO:0000313|EMBL:EAR85223.1};
GN ORFNames=TTHERM_00486740 {ECO:0000313|EMBL:EAR85223.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR85223.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MOS2 family.
CC {ECO:0000256|ARBA:ARBA00010966}.
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DR EMBL; GG662587; EAR85223.1; -; Genomic_DNA.
DR RefSeq; XP_001032886.1; XM_001032886.1.
DR AlphaFoldDB; I7MGJ4; -.
DR STRING; 312017.I7MGJ4; -.
DR EnsemblProtists; EAR85223; EAR85223; TTHERM_00486740.
DR GeneID; 7846958; -.
DR KEGG; tet:TTHERM_00486740; -.
DR eggNOG; KOG4315; Eukaryota.
DR HOGENOM; CLU_045183_0_0_1; -.
DR InParanoid; I7MGJ4; -.
DR OMA; AHKDKEK; -.
DR OrthoDB; 103614at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd13153; KOW_GPKOW_B; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.30.30.30; -; 2.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR041994; GPKOW_KOW2.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR045166; Spp2-like.
DR InterPro; IPR026822; Spp2/MOS2_G-patch.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR15818; G PATCH AND KOW-CONTAINING; 1.
DR PANTHER; PTHR15818:SF2; G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN; 1.
DR Pfam; PF12656; G-patch_2; 1.
DR Pfam; PF00467; KOW; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00739; KOW; 2.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 40..85
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 185..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..262
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 43270 MW; C9FC3C9FFAFCE326 CRC64;
MSSQQPDSPT IQNVPLQERH LMQEKVAEDI SKEAYDYMPV ESFGSFLIKK MGYDEKQGIG
RKQQIVRPIE FVPRNHRQGL GADPMPSFLQ KQKDGKEIPK GLQNLVSKTG KSYNYIGDKL
IDKNKQIDIN DKVNIIAGKH EGLQGFITKV DKEKEEYLVE LKNGQVVKVD KKQVKLIIPE
LEKMQEETKH KEQSDSESEA SSQGNAESDQ SESSDDEKSS SDHEKKAKKS KKIKKDKDKK
DKKSKKDKKS KKDKKKKKDS KKKRLKWVEP LIRIRIISKK YKDGQFYNVK AIISDIIDCY
TFTVITPSKN TLEDLREKDI ETIIPDIGKK VKVLTGENKG HVATLLERNK RKNEVVVQIV
DTMETIILSQ DDVSEVVA
//
