ID I7MGS2_TETTS Unreviewed; 883 AA.
AC I7MGS2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Bromodomain domain protein {ECO:0000313|EMBL:EAS01966.3};
GN ORFNames=TTHERM_00499530 {ECO:0000313|EMBL:EAS01966.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS01966.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662548; EAS01966.3; -; Genomic_DNA.
DR RefSeq; XP_001022211.3; XM_001022211.3.
DR AlphaFoldDB; I7MGS2; -.
DR STRING; 312017.I7MGS2; -.
DR GeneID; 7838178; -.
DR KEGG; tet:TTHERM_00499530; -.
DR eggNOG; KOG1474; Eukaryota.
DR InParanoid; I7MGS2; -.
DR OrthoDB; 276851at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR CDD; cd04369; Bromodomain; 1.
DR Gene3D; 1.20.1270.220; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR45926:SF6; HOMEOTIC PROTEIN FEMALE STERILE-RELATED; 1.
DR PANTHER; PTHR45926; OSJNBA0053K19.4 PROTEIN; 1.
DR Pfam; PF17035; BET; 2.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51525; NET; 2.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 169..241
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 349..427
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT DOMAIN 476..553
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 63..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 100784 MW; DE3CC72BAA2028F4 CRC64;
MSDQVQEIFL TQEQSKYINS MLPRGYSLQF SSSHTRRVQM NPNATKLNQY EQTLIQERLK
QTRSKMNQAA NAQNAASLAA QQNKNDKDKK LQSKKENIPE KEQIADSPES GNTKKRKQQE
KILEKQAAKS LKQQNQVLQQ VISVDTQQKG TIPVSEDIRV CFSILQQLKK SENAGPFLQK
VDALAQQCPD YYKIIRDPMD LSKVESNLKQ GYYQTTLQFA DDVRKIWNNS FTYNQKGSQI
YKMTEEMSRL FEKIFTQVKS QSLPNPMEYQ DSIDASSNSI NNNTASSLKK RANKQAQNVT
QQQNQIQQLS SASVPITQNS AIPANPPKPE KQKKTKQTAN QPDTTAQQAK AKDKYQTKLS
QDEINQLYQN IGSLTEDDTK QLYELIKDYC ETNNEQIELN IDNLPIKTAR EVQEFVLFKR
RLPSQQQVNQ QQQQQQQLQQ QQQLQQQQQL QQQQIQQQKQ QQSQDEQQDN KKKKKIGKLE
KKDIPLTISE KKQLGINIRR LPPEDLNGIW SIVQDSQQNS EVIEFDIDTL PVRKARELEA
YVKQRAAFQQ KKQRVQKNQP NNLLSDSQQQ AKAQLPYSTP TTTTTASTTV NTNQTPIDAA
VNNFPQQTSF TAAQQYPATA YASNPGYTQA NQLIQNNGSA QNAASAKVNN SQMIQQGQYV
QANPVAQQQL PIAQATTQQN MASIQGYNHL NQQQYAQQST YQNQMMMNQY PSAFPIQQPM
QSAVIGGYQN RPSQQYDAGQ QGMAIPSMIN QTQQPYSGQQ YNQQGQAQYQ GYGNNMQNMY
MNQPLSANSN GNHNRNIVPN QQIQYGANTQ VQNGISQYPQ SQNYYNAQYQ SNPSQYQQHL
QQMNVNPQYS SNSNQAQQYN GHIQNQNNSE QSSEAMLSES EEE
//
