ID I7MHK4_TETTS Unreviewed; 1096 AA.
AC I7MHK4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Kinesin motor catalytic domain protein {ECO:0000313|EMBL:EAS03052.3};
GN ORFNames=TTHERM_00444350 {ECO:0000313|EMBL:EAS03052.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS03052.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; GG662504; EAS03052.3; -; Genomic_DNA.
DR RefSeq; XP_001023297.3; XM_001023297.3.
DR AlphaFoldDB; I7MHK4; -.
DR STRING; 312017.I7MHK4; -.
DR GeneID; 7826931; -.
DR KEGG; tet:TTHERM_00444350; -.
DR eggNOG; KOG0240; Eukaryota.
DR InParanoid; I7MHK4; -.
DR OrthoDB; 5481713at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01369; KISc_KHC_KIF5; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF36; CENTROMERE-ASSOCIATED PROTEIN E; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 11..334
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 408..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 339..373
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 466..539
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 768..838
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 419..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 94..101
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1096 AA; 125088 MW; 03D4AB7C0E2D3234 CRC64;
MSKKNQQESN NIRVVLRCRP LNKLEIEQGG EQCVKIVDDS TVQVIVAGEE QPHQFSFDKI
FPSDTRQIDV FKEVGQPVLE CIMQGINSTI FAYGQTSSGK THTMEGKHDD PEYMGLIPRM
MDKLFDMIAD APSTIEFSIK ASFLEIYNEK IHDLLDPSKT NLNVKEDKLR GIFVQDATEA
FVVKASDMMK VMRKGADNRS VAATRMNERS SRSHSIFLLT LIQKNTETET SRLSKLYFVD
LAGSEKIAKT HVSGQQLEEA KNINKSLTCL GIVINSLSEK KEHIPYRDSK LTRILQESIG
GNSKTTLIIA CSMCSYNDKE TISTLRFGQR AKSIKNQAKV NEEKSAKELM QLLAKAENMI
KYKDEIIAAL QQQLGQENIT PVAPNKQLSK SNSVADISFS FNRQLTRSET EIEENTRNIE
NESPSIQLKP VAPQEQQETA KPKKSTPTNK LGGVQKQNNP NTSRKLLEQH LEIIKLKEKI
EKLEGEKHDL EIDLANKTTE LQMSNEKCKS MSEAMEQTYT DCEAQLKKYQ DQMENMQVDT
LEWNTYTREL KKSTNRLQSD LNYLLLSTEI KSMDIKNIDA NGFESQEGKI CQTIKKTLEQ
IDAINSYIGK FEQVQSLRTM TEGSETDERK MKTVGDEDKP HKKKEDIKLK SFVSPRSKHG
GFIRLQQSTS DYNEVLSTEA DDVIFTEDSI PSTTSNTGTN GSNYLKDNNM QQPTDQLIME
RNESEDEDHT EEEEDIKDII EITKSITSLD EVQREELMTY IISIKRQVRK LTQQNKEYVL
NIENYQSSSD CQIQKYKKKI QEIKKTLNQK LKDQEIKLLN LSTKLNEKAT EIKNLTLKHE
KELIDKNQTY ANLKVEFENL KKVISSNHPV SKIAELQQKI KELGTDRQKL FNELFAARNE
LDQKEITLKE KDSQIQLMRK TMQKQNGEFN NIKSGGDFLV SSRGALLERK TTVNDLDSSG
QKQKSISLKS HIAPSIRGGG GDFASFQKNN QYLLSDEANE DNYDDNTDPK LRNTKQQEIS
KSINTFDQKM KHAQLSSTKK TMNRIDEEDD MANDFAQIEP SAFELEKKFN IIGQKKIETE
KSTTSSIFGA VKKIFM
//