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Database: UniProt
Entry: I7MHK4_TETTS
LinkDB: I7MHK4_TETTS
Original site: I7MHK4_TETTS 
ID   I7MHK4_TETTS            Unreviewed;      1096 AA.
AC   I7MHK4;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Kinesin motor catalytic domain protein {ECO:0000313|EMBL:EAS03052.3};
GN   ORFNames=TTHERM_00444350 {ECO:0000313|EMBL:EAS03052.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS03052.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR   EMBL; GG662504; EAS03052.3; -; Genomic_DNA.
DR   RefSeq; XP_001023297.3; XM_001023297.3.
DR   AlphaFoldDB; I7MHK4; -.
DR   STRING; 312017.I7MHK4; -.
DR   GeneID; 7826931; -.
DR   KEGG; tet:TTHERM_00444350; -.
DR   eggNOG; KOG0240; Eukaryota.
DR   InParanoid; I7MHK4; -.
DR   OrthoDB; 5481713at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   CDD; cd01369; KISc_KHC_KIF5; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR   PANTHER; PTHR47968:SF36; CENTROMERE-ASSOCIATED PROTEIN E; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          11..334
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS50067"
FT   REGION          408..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          619..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          688..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          339..373
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          466..539
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          768..838
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        419..463
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..643
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         94..101
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   1096 AA;  125088 MW;  03D4AB7C0E2D3234 CRC64;
     MSKKNQQESN NIRVVLRCRP LNKLEIEQGG EQCVKIVDDS TVQVIVAGEE QPHQFSFDKI
     FPSDTRQIDV FKEVGQPVLE CIMQGINSTI FAYGQTSSGK THTMEGKHDD PEYMGLIPRM
     MDKLFDMIAD APSTIEFSIK ASFLEIYNEK IHDLLDPSKT NLNVKEDKLR GIFVQDATEA
     FVVKASDMMK VMRKGADNRS VAATRMNERS SRSHSIFLLT LIQKNTETET SRLSKLYFVD
     LAGSEKIAKT HVSGQQLEEA KNINKSLTCL GIVINSLSEK KEHIPYRDSK LTRILQESIG
     GNSKTTLIIA CSMCSYNDKE TISTLRFGQR AKSIKNQAKV NEEKSAKELM QLLAKAENMI
     KYKDEIIAAL QQQLGQENIT PVAPNKQLSK SNSVADISFS FNRQLTRSET EIEENTRNIE
     NESPSIQLKP VAPQEQQETA KPKKSTPTNK LGGVQKQNNP NTSRKLLEQH LEIIKLKEKI
     EKLEGEKHDL EIDLANKTTE LQMSNEKCKS MSEAMEQTYT DCEAQLKKYQ DQMENMQVDT
     LEWNTYTREL KKSTNRLQSD LNYLLLSTEI KSMDIKNIDA NGFESQEGKI CQTIKKTLEQ
     IDAINSYIGK FEQVQSLRTM TEGSETDERK MKTVGDEDKP HKKKEDIKLK SFVSPRSKHG
     GFIRLQQSTS DYNEVLSTEA DDVIFTEDSI PSTTSNTGTN GSNYLKDNNM QQPTDQLIME
     RNESEDEDHT EEEEDIKDII EITKSITSLD EVQREELMTY IISIKRQVRK LTQQNKEYVL
     NIENYQSSSD CQIQKYKKKI QEIKKTLNQK LKDQEIKLLN LSTKLNEKAT EIKNLTLKHE
     KELIDKNQTY ANLKVEFENL KKVISSNHPV SKIAELQQKI KELGTDRQKL FNELFAARNE
     LDQKEITLKE KDSQIQLMRK TMQKQNGEFN NIKSGGDFLV SSRGALLERK TTVNDLDSSG
     QKQKSISLKS HIAPSIRGGG GDFASFQKNN QYLLSDEANE DNYDDNTDPK LRNTKQQEIS
     KSINTFDQKM KHAQLSSTKK TMNRIDEEDD MANDFAQIEP SAFELEKKFN IIGQKKIETE
     KSTTSSIFGA VKKIFM
//
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