ID I7MJV7_TETTS Unreviewed; 636 AA.
AC I7MJV7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=asparaginase {ECO:0000256|ARBA:ARBA00012920};
DE EC=3.5.1.1 {ECO:0000256|ARBA:ARBA00012920};
GN ORFNames=TTHERM_00483700 {ECO:0000313|EMBL:EAR97237.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR97237.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662667; EAR97237.1; -; Genomic_DNA.
DR RefSeq; XP_001017482.1; XM_001017482.1.
DR AlphaFoldDB; I7MJV7; -.
DR SMR; I7MJV7; -.
DR STRING; 312017.I7MJV7; -.
DR EnsemblProtists; EAR97237; EAR97237; TTHERM_00483700.
DR GeneID; 7840821; -.
DR KEGG; tet:TTHERM_00483700; -.
DR eggNOG; KOG0503; Eukaryota.
DR HOGENOM; CLU_019134_3_0_1; -.
DR InParanoid; I7MJV7; -.
DR OMA; NCVCYLI; -.
DR OrthoDB; 1421816at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009066; P:aspartate family amino acid metabolic process; IEA:UniProt.
DR CDD; cd08963; L-asparaginase_I; 1.
DR Gene3D; 3.40.50.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.1170; L-asparaginase, N-terminal domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR006033; AsnA_fam.
DR InterPro; IPR036152; Asp/glu_Ase-like_sf.
DR InterPro; IPR006034; Asparaginase/glutaminase-like.
DR InterPro; IPR040919; Asparaginase_C.
DR InterPro; IPR027473; L-asparaginase_C.
DR InterPro; IPR041725; L-asparaginase_I.
DR InterPro; IPR027474; L-asparaginase_N.
DR InterPro; IPR037152; L-asparaginase_N_sf.
DR NCBIfam; TIGR00519; asnASE_I; 1.
DR PANTHER; PTHR11707:SF28; 60 KDA LYSOPHOSPHOLIPASE; 1.
DR PANTHER; PTHR11707; L-ASPARAGINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00710; Asparaginase; 1.
DR Pfam; PF17763; Asparaginase_C; 1.
DR PIRSF; PIRSF001220; L-ASNase_gatD; 1.
DR PIRSF; PIRSF500176; L_ASNase; 1.
DR PRINTS; PR00139; ASNGLNASE.
DR SFLD; SFLDS00057; Glutaminase/Asparaginase; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00870; Asparaginase; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF53774; Glutaminase/Asparaginase; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51732; ASN_GLN_ASE_3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 57..265
FT /note="L-asparaginase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00710"
FT DOMAIN 284..398
FT /note="Asparaginase/glutaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17763"
FT REPEAT 480..512
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 73183 MW; B70673B4607AFE06 CRC64;
MNQKLELEQQ NSIHLHSQNS QSQERKKEFD KHQAVVFREK HNLECSQGLR IANQSRKVLI
ICTGGTISMF PTENGLAVKK GFFEKFLRED SYFCDSDYTY FHSSDGFLIT PLTIYQQRIW
YKIYELENPI DSTNMNVIYY DQIASIIETN YTLYDSFIIL HGTDTMAYTA SALSFMLENL
SKTVILTGSQ IPCSMMRNDG FNNLLCSLTI AGHYTIPEVL VCFNDKLFRG NRCTKMDSSA
MDSFDSPNFE PLATFKITIK IKWDKVLKRD PEKKFHVQKN LCDKIAIVKM HPFISSDTLK
AILTNKDTKA IIIETYGAGN IPINRPELMQ MLQEAYDQGK VIVNLSQCYK SKVESIYETG
RALLKVGVLC GWDCTTEAMA SKLAYLFSKN DSIENIRKNV QKNLRGELSP PIENDMFEFQ
QENFIQALND ALQYRTNEKI DILKNLILPN IVCYMSKGGF HQSMQQLKVY GIDFDKGDYD
NRTGLHLSAR EGQLETVKFL IKECKNINTV DKFGRTALFE AVINRHHDVI VELQRAGGII
QAPKQEITSI LMEAIRTGDQ ELFDLFHLGG LQDWNTFQTV DGRNLGHVAA TFRQIEIIRF
LKYQCKFRFT DKDRWGKTAL DEAKKRDFKE ICKLLS
//
