ID I7ML05_TETTS Unreviewed; 1378 AA.
AC I7ML05;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EAS00807.2};
GN ORFNames=TTHERM_00307780 {ECO:0000313|EMBL:EAS00807.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS00807.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662608; EAS00807.2; -; Genomic_DNA.
DR RefSeq; XP_001021052.2; XM_001021052.2.
DR GeneID; 7838971; -.
DR KEGG; tet:TTHERM_00307780; -.
DR eggNOG; KOG0501; Eukaryota.
DR InParanoid; I7ML05; -.
DR OrthoDB; 66005at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 647..754
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 110..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1378 AA; 159534 MW; 6E66CAB7764E38D7 CRC64;
MSKKAKNQEY NIERQLQELW FNLDYSNNSQ IKKNAIFDTT TINKDSIVGL DNHSLSKSLD
MLPKQASFQK NNLINQPTEQ LRGDEDDDQI FSPIYVENKV VLNKASKLSF DIKPPHKNSR
QTSTSNPSKN DESQSYQMNN DRLDINNINL LPSYRKTSQL NDTEVNQTNR EDSYTTNNMQ
IFLKINNNKE NTQRSQVNLK QWQSSNFSQA ALNISPKGKE QEGVSLNHNW KRGAFSILQK
IAQFRKIMLV KSDSKKFKKL KATDFAIIGD KASDFKYYVY KGFLESQRPT KIQKCVYQTT
KIIKNFFSSV FEKLSLSILK PDSNFKVLWD ILMLLLIWIN LIICPLIFSF DEFEIQDKML
LFMVFTCFAF ATDIIVQINT AFFHQGIIQT SRQQIIAKYF KQSMIPDIVT FFCYVRGVFT
GDKYLLLAIL LKTIKEIKIQ SSLQEVFQPT EKFMLAIRVF NVFQLVFIIA HFASCIFNWV
ASIQYDGKQQ DDLPYVETWL SANHLIGADW YKIYINGFYF SMISMMTIGY GDITPKSINE
KIYTIFFCVV SCASFAYSIN TISQVITDAK KKSKNFKERM RSLNLLMQNR QIDNHLQMKV
RKYIEYLQET SENMDYAYKD LEVLPTSIKQ DVQIDMYGNL IKKQKLFYLN FSQETIEKLA
LAVNEISAGP GEVIYKPNDS PDSLYIVLSG RIEIYIQSQK INGVENETNI AYIEKGCVFG
AEEFFNQKPR QNAAKATELS QIIQIQRNQL EQVLKSSEDD YEHFKMLSDM VKYSNTTRGL
GIQCHFCKNF THSFSECPNV TYSKRKNLII MKLNISQDQQ RDYYPRKHIK SKNSLLYQNF
LVKSIKLFID LKKYETKDTE NQDGMISGAS EQFDDAAVED NELNQIITEY TQKLRNTQKT
EEESEISYDD AQQKYNETNI AQKLNQKPEQ VSMLYAEQFL SNNNNNSGDE KDNKKGNSRT
SNTNKQSEEV LSSPNINSQI PNSLTFIQNN SPTFNQNVNQ EDNSCSQLQT FQLSTNPQLQ
VPQQFPERER HSSIQRMYPG EIKLFPLFSN TPQETRITRQ TSIDFTIQNQ LSNLYPQKQS
TNNFNSDFKN SNYASDFKNS KSSSLAQNYT QQLQSQQSNI INTNSQNSQN LGFQSMHQQQ
QPLSPQLVSE IQKQKQIIQD ASLMKLNTVT SNINTLGGKL DSKPTQNLGS QLTSFENMKM
GSQSFVQLSF NTKLGTDAKG VQSINGKEIV SSVNQNLIQQ ETKMLNQQQS QNQMILDNSI
EIHSIREIKG LNNWESETLK RFDRFKIFKK YFPLQNINKI LEVLNQRKNS KGSPSNKKQR
KKLTMLKKYD ILLKSFHASE FSPRKSILSK NLNLTNQNSE YLKRIIPSNS KFESQKDD
//