ID I7MMX0_TETTS Unreviewed; 536 AA.
AC I7MMX0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Copine protein {ECO:0000313|EMBL:EAS07125.1};
GN ORFNames=TTHERM_00683310 {ECO:0000313|EMBL:EAS07125.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS07125.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the copine family.
CC {ECO:0000256|ARBA:ARBA00009048}.
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DR EMBL; GG662247; EAS07125.1; -; Genomic_DNA.
DR RefSeq; XP_001027367.1; XM_001027367.1.
DR AlphaFoldDB; I7MMX0; -.
DR STRING; 312017.I7MMX0; -.
DR EnsemblProtists; EAS07125; EAS07125; TTHERM_00683310.
DR GeneID; 7839161; -.
DR KEGG; tet:TTHERM_00683310; -.
DR eggNOG; KOG1327; Eukaryota.
DR HOGENOM; CLU_020452_3_2_1; -.
DR InParanoid; I7MMX0; -.
DR OMA; CGVIIFA; -.
DR OrthoDB; 672483at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR CDD; cd04048; C2A_Copine; 1.
DR CDD; cd04047; C2B_Copine; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037768; C2B_Copine.
DR InterPro; IPR045052; Copine.
DR InterPro; IPR010734; Copine_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10857; COPINE; 1.
DR PANTHER; PTHR10857:SF106; NICOTINIC RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF07002; Copine; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50004; C2; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 1..115
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 125..252
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 536 AA; 60684 MW; 9B1B78D9636F445A CRC64;
MIGLQSDLVQ KIEIIISCRS LKDADVFSKS DPFVSFKMKN NQTNQWYEIG HTETVKDCLN
PNFKKIFQVD YTFEQKQEIL LEVLDDDGKG SADHIGLCQT TIGAIVGARN NTLILDLINK
KTQKKIEKSK IIIISDKVSE CNSSIITQWQ GQKLTNTDGW FDKSDPFLRF KKIKDQNTFI
QEYETEVVKD NLNPIWKLCE LSLGKLCGGD FFRPIKVECW DWEKSGKHQF IGEFTFTVDE
LNKGKREFIL TNPKIKKPGT IVLTRYDYVE KPTFLQYIRG NTQLNLMVAV DFTASNGAVS
TPQSLHYMNP QVMNQYQQAI HSVGEILLDY DFDKKVPCFG FGGVPRYPNY TFPNVQHCFP
LSGQPNNIEA FGLGEILNLY SYSLQHVSLS GPTLFNPILT EACRISQILK QNGSQVYTVL
LIITDGEIHD MNETIDTIVN ASNLPLSVVI VGVGNADFTN MNRLDGDNGR LTNSKGQQSI
RDFVQFVPFR NFQGNGFALC KEVLAEIPTQ LEQYMIANNI KPQQAPLINP CQVAMN
//
