ID I8HX28_9GAMM Unreviewed; 587 AA.
AC I8HX28;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Biopterin-dependent aromatic amino acid hydroxylase domain protein {ECO:0000313|EMBL:EIT67926.1};
GN ORFNames=WQQ_43610 {ECO:0000313|EMBL:EIT67926.1};
OS Hydrocarboniphaga effusa AP103.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Nevskiales; Nevskiaceae;
OC Hydrocarboniphaga.
OX NCBI_TaxID=1172194 {ECO:0000313|EMBL:EIT67926.1, ECO:0000313|Proteomes:UP000003704};
RN [1] {ECO:0000313|EMBL:EIT67926.1, ECO:0000313|Proteomes:UP000003704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP103 {ECO:0000313|EMBL:EIT67926.1,
RC ECO:0000313|Proteomes:UP000003704};
RX PubMed=22933753; DOI=10.1128/JB.01017-12;
RA Chang H.K., Zylstra G.J., Chae J.C.;
RT "Genome Sequence of n-Alkane-Degrading Hydrocarboniphaga effusa Strain
RT AP103T (ATCC BAA-332T).";
RL J. Bacteriol. 194:5120-5120(2012).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIT67926.1}.
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DR EMBL; AKGD01000004; EIT67926.1; -; Genomic_DNA.
DR RefSeq; WP_007187296.1; NZ_AKGD01000004.1.
DR AlphaFoldDB; I8HX28; -.
DR STRING; 1172194.WQQ_43610; -.
DR PATRIC; fig|1172194.4.peg.4227; -.
DR OrthoDB; 9780502at2; -.
DR Proteomes; UP000003704; Unassembled WGS sequence.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000003704}.
FT DOMAIN 1..340
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 128
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 133
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 218
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 587 AA; 64451 MW; E639CE656B13F4D5 CRC64;
MPTQAQIIAR LPRHLRPYAC VQDYARYTAR DHAVWRFIMR QLTRSLEHSA HPVYFEGLKK
TGIRLDRIPS IDEMNRCLEP LGWSALVVDG YIPTSVFSEF QMRRILAIAM DMRSIDNILY
TPAPDIVHES AGHAPFIVDV DYAEYLQRFG EISMKAISTQ ADHAVFLAIR ALSALKEARN
ASDAELANAQ AGLDAALAAN DHSSEAARLA RLQWWTIEYG LVGDVADYKL FGAGLLSSLG
ESRSCLDDGA VRKLPLTVEA VNTPYDITRP QPQLFVARSC QHLTQVLEVF AQGMCFRKGG
AESLRVAIDS GSVCTARYNS GLEVGGVFDR VLTDAIGNAI YLGTRGPTQL AFQGRELVGH
GVETHAEGYG SPVGRLQGLP RCLSDYSVDE LKSLGIAVGR NVRLDYLSGI RVQGRLDSLR
RESGRNLIFS FSDCTVTGLA GERLFEPHWG RYDLGVGEAI VSVCGGPADR ESLADTEAFD
TTTREPAQPS PTDRQLDAIY ADLRALRERG APASSDLQPI ENALQRFPGE WLARLELLEL
ANADRAERLQ RELAHLAQCD ADKRPLIEMG LGGLSEATTR PAPSRTA
//
