UniProt: I8R8J0

Database: UniProt
Entry: I8R8J0_LACPE

LinkDB:  I8R8J0_LACPE 
Original site:  I8R8J0_LACPE

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Ontology (3)   
   GO (3)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (5)   
   InterPro (3)   
   Pfam (1)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (12)   

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ID   I8R8J0_LACPE            Unreviewed;       453 AA.
AC   I8R8J0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Permease IIC component {ECO:0000256|PIRNR:PIRNR006351};
GN   Name=pts7C {ECO:0000313|EMBL:EIW14988.1};
GN   ORFNames=KCA1_0369 {ECO:0000313|EMBL:EIW14988.1};
OS   Lactiplantibacillus pentosus KCA1.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=1136177 {ECO:0000313|EMBL:EIW14988.1};
RN   [1] {ECO:0000313|EMBL:EIW14988.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCA1 {ECO:0000313|EMBL:EIW14988.1};
RX   PubMed=23527145;
RA   Anukam K.C., Macklaim J.M., Gloor G.B., Reid G., Boekhorst J., Renckens B.,
RA   van Hijum S.A., Siezen R.J.;
RT   "Genome Sequence of Lactobacillus pentosus KCA1: Vaginal Isolate from a
RT   Healthy Premenopausal Woman.";
RL   PLoS ONE 8:E59239-E59239(2013).
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC       system (PTS), a major carbohydrate active -transport system, catalyzes
CC       the phosphorylation of incoming sugar substrates concomitant with their
CC       translocation across the cell membrane.
CC       {ECO:0000256|PIRNR:PIRNR006351}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIW14988.1}.
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DR   EMBL; AKAO01000008; EIW14988.1; -; Genomic_DNA.
DR   RefSeq; WP_003637622.1; NZ_CM001538.1.
DR   AlphaFoldDB; I8R8J0; -.
DR   GeneID; 49392792; -.
DR   PATRIC; fig|1136177.4.peg.2732; -.
DR   eggNOG; COG1455; Bacteria.
DR   HOGENOM; CLU_029688_1_2_9; -.
DR   Proteomes; UP000005826; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR004501; PTS_EIIC_3.
DR   InterPro; IPR004796; PTS_IIC_cello.
DR   NCBIfam; TIGR00410; lacE; 1.
DR   PANTHER; PTHR33989; -; 1.
DR   PANTHER; PTHR33989:SF4; PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIC COMPONENT; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   PIRSF; PIRSF006351; PTS_EIIC-Cellobiose; 1.
DR   PROSITE; PS51105; PTS_EIIC_TYPE_3; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR006351};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR006351};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW   ECO:0000256|PIRNR:PIRNR006351}; Transferase {ECO:0000313|EMBL:EIW14988.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR006351}.
FT   TRANSMEM        31..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        165..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        207..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        314..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..439
FT                   /note="PTS EIIC type-3"
FT                   /evidence="ECO:0000259|PROSITE:PS51105"
SQ   SEQUENCE   453 AA;  49257 MW;  B916F47DCFA1FB06 CRC64;
     MNSFIEWLNK HLVPIAAKIG AVRWLVALRD AFIAIMPAMM AGSIATVLNA LVRDIPTKFG
     WMGFVNSMQW LIGINAMVWT GTLAILGLIF SFTFGYQLAI QYKVEPVTGG IVTLGTFIMS
     LPQNFTGTLT STLSKGATKI LTDSGMAVAG KKVTAWGYFN FNTYFGSYGF FTVMILGAIA
     SVVYIALMKK HITIKMPDSV PPAVANAFTG VIPAAAAFYV VGIINWIFSK FNTTVIEWIA
     KIIQEPLLNM SQGYGAVLLM TLLVQVFWFF GIHGSNVLAP ILDGIWLTAQ LANVNAYQAG
     KALPYVWTRN CFDLYAWIGG AGSTLLLLVA ILVFSKRDDQ RSVAKLAIGP GFFNINEPVM
     FGMPIVLDPI YFIPFVLAPV VTVSIAYAAL AAGWVAPITN NIVWSMPPIM NALVATMDWR
     SVVLQLFNAA VAFIIYVPFV KAANKIKPAA IGE
//

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