ID I8TDP3_9GAMM Unreviewed; 359 AA.
AC I8TDP3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=WQQ_22270 {ECO:0000313|EMBL:EIT72090.1};
OS Hydrocarboniphaga effusa AP103.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Nevskiales; Nevskiaceae;
OC Hydrocarboniphaga.
OX NCBI_TaxID=1172194 {ECO:0000313|EMBL:EIT72090.1, ECO:0000313|Proteomes:UP000003704};
RN [1] {ECO:0000313|EMBL:EIT72090.1, ECO:0000313|Proteomes:UP000003704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP103 {ECO:0000313|EMBL:EIT72090.1,
RC ECO:0000313|Proteomes:UP000003704};
RX PubMed=22933753; DOI=10.1128/JB.01017-12;
RA Chang H.K., Zylstra G.J., Chae J.C.;
RT "Genome Sequence of n-Alkane-Degrading Hydrocarboniphaga effusa Strain
RT AP103T (ATCC BAA-332T).";
RL J. Bacteriol. 194:5120-5120(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIT72090.1}.
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DR EMBL; AKGD01000001; EIT72090.1; -; Genomic_DNA.
DR AlphaFoldDB; I8TDP3; -.
DR STRING; 1172194.WQQ_22270; -.
DR PATRIC; fig|1172194.4.peg.2150; -.
DR Proteomes; UP000003704; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EIT72090.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003704};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 48..96
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 109..317
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 359 AA; 41239 MW; 6DFADBC245C87E8E CRC64;
MLMDMDAPIT IDSRNELSEL AEMAARSAGL RYVAAGEPGI RRERDGRGFR YLDTRGRVIR
DTDVLERIRK LAIPPAYENV WICRNERGHL QATGIDARGR KQYRYHPRWR SVRDGAKFER
MVEFGEALPR LRRRVRHDLA RKGLPREKVL AVIVALLDST LVRIGNHEYS RSNKSYGLTT
LRDRHVSFVR DGRALLRFRG KGGLEREIVV NDRRLAGIVR RCRQIPGQQL FQYLDDEGEQ
HPVDSGQVND YLREATGQDF TAKDFRTWGG TLRAIALMGC TPMPELVSER SLTQCINHAI
KQVASELGNT PAVCRKSYIN PVVFEAWRDG RLHKVVREDL SRAPRKAETL ALRFLKRVT
//
