ID   I9L3J5_LACPE            Unreviewed;       178 AA.
AC   I9L3J5;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=dUTP diphosphatase {ECO:0000256|ARBA:ARBA00012379};
DE            EC=3.6.1.23 {ECO:0000256|ARBA:ARBA00012379};
GN   Name=dut {ECO:0000313|EMBL:EIW14884.1};
GN   ORFNames=KCA1_0514 {ECO:0000313|EMBL:EIW14884.1};
OS   Lactiplantibacillus pentosus KCA1.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=1136177 {ECO:0000313|EMBL:EIW14884.1};
RN   [1] {ECO:0000313|EMBL:EIW14884.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCA1 {ECO:0000313|EMBL:EIW14884.1};
RX   PubMed=23527145;
RA   Anukam K.C., Macklaim J.M., Gloor G.B., Reid G., Boekhorst J., Renckens B.,
RA   van Hijum S.A., Siezen R.J.;
RT   "Genome Sequence of Lactobacillus pentosus KCA1: Vaginal Isolate from a
RT   Healthy Premenopausal Woman.";
RL   PLoS ONE 8:E59239-E59239(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23;
CC         Evidence={ECO:0000256|ARBA:ARBA00000878};
CC   -!- SIMILARITY: Belongs to the dUTPase family.
CC       {ECO:0000256|ARBA:ARBA00006581}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIW14884.1}.
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DR   EMBL; AKAO01000015; EIW14884.1; -; Genomic_DNA.
DR   RefSeq; WP_003637759.1; NZ_CM001538.1.
DR   AlphaFoldDB; I9L3J5; -.
DR   PATRIC; fig|1136177.4.peg.99; -.
DR   eggNOG; COG0756; Bacteria.
DR   HOGENOM; CLU_068508_0_0_9; -.
DR   Proteomes; UP000005826; Chromosome.
DR   GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006226; P:dUMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0046081; P:dUTP catabolic process; IEA:InterPro.
DR   CDD; cd07557; trimeric_dUTPase; 1.
DR   Gene3D; 2.70.40.10; -; 1.
DR   InterPro; IPR008181; dUTPase.
DR   InterPro; IPR029054; dUTPase-like.
DR   InterPro; IPR036157; dUTPase-like_sf.
DR   InterPro; IPR033704; dUTPase_trimeric.
DR   PANTHER; PTHR11241; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR   PANTHER; PTHR11241:SF0; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR   Pfam; PF00692; dUTPase; 1.
DR   SUPFAM; SSF51283; dUTPase-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EIW14884.1};
KW   Nucleotide metabolism {ECO:0000256|ARBA:ARBA00023080}.
FT   DOMAIN          68..176
FT                   /note="dUTPase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00692"
SQ   SEQUENCE   178 AA;  19792 MW;  893A393B982567FF CRC64;
     MARGFKIVSQ YAQAGLHLPY RATKQAAGYD FEAAEDFTLP SIWKLNFIKV LWQLHRSEKS
     STADLDAAAK VLKPWLVPTG IKAFMNDGEY LLLANRSSNP LKRNLILPNG IGVIDADYYD
     NPKNEGAIFV QLINMGIRDV HIKKGERIAQ GIFTPYLTVT DEENVTTTRS GGFGSTNK
//