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Database: UniProt
Entry: I9P4D7_9ALTE
LinkDB: I9P4D7_9ALTE
Original site: I9P4D7_9ALTE 
ID   I9P4D7_9ALTE            Unreviewed;       297 AA.
AC   I9P4D7;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   28-FEB-2018, entry version 34.
DE   RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000256|RuleBase:RU910714};
DE            Short=HIBADH {ECO:0000256|RuleBase:RU910714};
DE            EC=1.1.1.31 {ECO:0000256|RuleBase:RU910714};
GN   ORFNames=AGRI_04301 {ECO:0000313|EMBL:EIW89837.1};
OS   Alishewanella agri BL06.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Alteromonadaceae; Alishewanella.
OX   NCBI_TaxID=1195246 {ECO:0000313|EMBL:EIW89837.1, ECO:0000313|Proteomes:UP000035062};
RN   [1] {ECO:0000313|EMBL:EIW89837.1, ECO:0000313|Proteomes:UP000035062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL06 {ECO:0000313|EMBL:EIW89837.1,
RC   ECO:0000313|Proteomes:UP000035062};
RX   PubMed=22933763; DOI=10.1128/JB.01129-12;
RA   Kim J., Jung J., Sung J.S., Chun J., Park W.;
RT   "Genome Sequence of Pectin-Degrading Alishewanella agri, Isolated from
RT   Landfill Soil.";
RL   J. Bacteriol. 194:5135-5136(2012).
CC   -!- CATALYTIC ACTIVITY: 3-hydroxy-2-methylpropanoate + NAD(+) = 2-
CC       methyl-3-oxopropanoate + NADH. {ECO:0000256|RuleBase:RU910714}.
CC   -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC       {ECO:0000256|RuleBase:RU910714}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyisobutyrate dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU910714}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EIW89837.1}.
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DR   EMBL; AKKU01000010; EIW89837.1; -; Genomic_DNA.
DR   RefSeq; WP_008983784.1; NZ_AKKU01000010.1.
DR   EnsemblBacteria; EIW89837; EIW89837; AGRI_04301.
DR   PATRIC; fig|1195246.3.peg.845; -.
DR   OrthoDB; POG091H02BQ; -.
DR   BioCyc; AAGR1195246:G1H6T-879-MONOMER; -.
DR   UniPathway; UPA00362; -.
DR   Proteomes; UP000035062; Unassembled WGS sequence.
DR   GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR   GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR011548; HIBADH.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01692; HIBADH; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   Branched-chain amino acid catabolism {ECO:0000256|RuleBase:RU910714};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035062};
KW   NAD {ECO:0000256|RuleBase:RU910714};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU910714};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035062}.
FT   DOMAIN        3    162       NAD_binding_2. {ECO:0000259|Pfam:
FT                                PF03446}.
FT   DOMAIN      165    290       NAD_binding_11. {ECO:0000259|Pfam:
FT                                PF14833}.
FT   ACT_SITE    171    171       {ECO:0000256|PIRSR:PIRSR000103-1}.
SQ   SEQUENCE   297 AA;  30366 MW;  D1B2BAD68E08D2E7 CRC64;
     MAKVAFIGLG NMGGPMAVNL VKAGHQVAAF DLSANALAQV KAEGAAVASS AADAVAGADF
     VISMLPAAKH VLSLYLGEQG IATHIDKKAL VIDCSTIDAD SARKLGAALA EQDLAFIDAP
     VSGGVGGAKA GTLTFIVGGS DADFERAKTV LGNMGKNLFH AGAVGAGQVA KICNNMLLSI
     LMVGTSEALQ MGIDNGLDPK VLSEIMLKSS GRNWTLELYN PCPDVLPNVP SSNGYQGGFM
     VDLMVKDLGL ALEASLQSGS STPLGALARS LYVAHQRAGN GKLDFSSIFT AFEKVKN
//
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