ID I9S0P5_9BACE Unreviewed; 941 AA.
AC I9S0P5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=HMPREF1068_02869 {ECO:0000313|EMBL:EIY48723.1};
OS Bacteroides nordii CL02T12C05.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997884 {ECO:0000313|EMBL:EIY48723.1, ECO:0000313|Proteomes:UP000003089};
RN [1] {ECO:0000313|EMBL:EIY48723.1, ECO:0000313|Proteomes:UP000003089}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL02T12C05 {ECO:0000313|EMBL:EIY48723.1,
RC ECO:0000313|Proteomes:UP000003089};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides nordii CL02T12C05.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY48723.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGXS01000019; EIY48723.1; -; Genomic_DNA.
DR RefSeq; WP_007485982.1; NZ_JH724314.1.
DR AlphaFoldDB; I9S0P5; -.
DR STRING; 997884.HMPREF1068_02869; -.
DR GeneID; 69501849; -.
DR PATRIC; fig|997884.3.peg.2947; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_10; -.
DR Proteomes; UP000003089; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000003089};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 608..930
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 941 AA; 105367 MW; 98E7A838DFB129E4 CRC64;
MQETEYINVY GARVHNLKDI DAEIPRNSLT VITGLSGSGK SSLAFDTIFA EGQRRYIETF
SAYARNFLGN LERPDVDKIT GLSPVISIEQ KTTNKNPRST VGTTTEIYDY LRLLYARAGI
AYSYLSGEKM VKYTEEQILD LILGDYKGKK IYMLAPLVRA RKGHYKELFE QVRKKGYLYV
RVDGEVREVT HGMKLDRYKN HDIEVVIDKM IVGDKDDKRL KQSVATAMRQ GDGLLMILDV
TTGELRHYSK RLMCPVTGLS YREPAPHNFS FNSPQGACPK CKGLGVVNQI DVDKVIPDRN
MSIYEGAIAP LGKYKNAMIF WQIGALLEKY EATLKTPVKD LPEDAMDEVL YGSDERIKIK
SSLIGTSSDY FVTYEGVVKY IQMLQEKDAS ATAQKWAEQF ARTTVCPECK GAKLNKEALH
FRIHDKNINE LSNMDISELY DWLQKVDEFL SDKQKKIAAE ILKEIRTRLK FLLDVGLDYL
SLNRSSVSLS GGESQRIRLA TQIGSQLVNV LYILDEPSIG LHQRDNLRLI NSLKELRDMG
NSVIVVEHDK DMMLASDYVI DMGPKAGRLG GEVVFAGKPQ EMLQTSTLTS QYLNGQQKIE
VPAKRRPGNG KSLWLRGAKG NNLKNVDVEF PLGKLICVTG VSGSGKSTLI NETLQPILSQ
KFYRSLQDPL EYGSIEGLEN IDKVVNVDQS PLGRTPRSNP ATYTGVFSDI RNLFVGLPEA
KIRGYKPGRF SFNVSGGRCE ACSGNGYKTI EMNFLPDVYV PCEVCHGKRY NRETLEVRFK
GKSIADVLDM TINRAVEFFE NVPQILNKIK VIQDVGLGYI KLGQSSTTLS GGESQRVKLA
TELSKRDTGK TLYILDEPTT GLHFEDIRVL MNVLNKLVDK GNTVIVIEHN LDVIKMADYI
IDMGPDGGKG GGKLLSFGTP EEVAKSKKGY TPKFLREELS L
//
