ID   I9S7D9_9BACE            Unreviewed;       736 AA.
AC   I9S7D9;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Dipeptidyl-peptidase IV {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1068_01198 {ECO:0000313|EMBL:EIY51651.1};
OS   Bacteroides nordii CL02T12C05.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=997884 {ECO:0000313|EMBL:EIY51651.1, ECO:0000313|Proteomes:UP000003089};
RN   [1] {ECO:0000313|EMBL:EIY51651.1, ECO:0000313|Proteomes:UP000003089}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL02T12C05 {ECO:0000313|EMBL:EIY51651.1,
RC   ECO:0000313|Proteomes:UP000003089};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA   Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA   Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA   Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Bacteroides nordii CL02T12C05.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIY51651.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AGXS01000015; EIY51651.1; -; Genomic_DNA.
DR   RefSeq; WP_007484163.1; NZ_JH724314.1.
DR   AlphaFoldDB; I9S7D9; -.
DR   STRING; 997884.HMPREF1068_01198; -.
DR   PATRIC; fig|997884.3.peg.1217; -.
DR   eggNOG; COG0823; Bacteria.
DR   eggNOG; COG1506; Bacteria.
DR   HOGENOM; CLU_006105_2_0_10; -.
DR   Proteomes; UP000003089; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003089};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..736
FT                   /note="Dipeptidyl-peptidase IV"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003725508"
FT   DOMAIN          97..454
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          538..736
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   736 AA;  83606 MW;  4AB6AF57B522639F CRC64;
     MKKLTLTLLL FLACVAGMAQ GSKKLDLKDI TSGQYRPTSI RNVVPMPDGE HYTQMNDEGT
     QITKYSFKTG EPVEVIFDVA KARECDFKHF DSYQFSLDGS KLLIATKTTP IYRRSYTAVH
     YLYPLKRNDK GVTTNNIIER LSDGGPQQAP VFSPDGTMIA FVRDNNIFLV KTLYGNSESQ
     VTEDGKQNAV LNGIPDWVYE EEFGFNRALE FSADNSMLAF IRFDETEVPS YQFPLFAGES
     PHINGLEDYP GEYTYKYPKA GYPNSKVEVR TFDIKSKVTR TMKLPLDADG YIPRIRFTQD
     PNKLAIMTLN RHQNRFDMYF ADPRSTVCKL ALRDESPYYI SENVFDNIQF YPENFSFLSD
     KDGYPHLYWY SMGGNLIKQV TKGAHEVESF LGYDEADGSF YFISNEESPM RQAVYKIDRK
     GKKTKLSQKA GMNSALFSPT MKYYINTYTN LDTPAVITLN DNEGKTLKTL EANNALKQKL
     AQVALPQKEF FKFKTSQGVE LNGWMMKPAD FSASKKYPVL MYQYSGPGSQ QVLDNFAISW
     ETYMASLGYI VACVDGRGTG GRGTEFQKST YLNLGVKEAK DQVEAAKYLG TLPYVDKNRI
     GIWGWSYGGY MAIMSMSEGT PVFKAGVAVA APTDWKFYDT IYTERFMRTP KENAEGYKAA
     SAFTRADKLH GNLLLVHGMA DDNVHFQNCA EYAEHLVQLD KQFDMQVYTN RNHGIYGGNT
     RQHLYTKLTN FFLNNL
//