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Database: UniProt
Entry: I9W8X7_9RALS
LinkDB: I9W8X7_9RALS
Original site: I9W8X7_9RALS 
ID   I9W8X7_9RALS            Unreviewed;       534 AA.
AC   I9W8X7;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   23-MAY-2018, entry version 21.
DE   RecName: Full=NAD(P) transhydrogenase subunit alpha {ECO:0000256|PIRNR:PIRNR000203};
DE            EC=1.6.1.2 {ECO:0000256|PIRNR:PIRNR000203};
GN   ORFNames=MW7_0395 {ECO:0000313|EMBL:EIZ05032.1};
OS   Ralstonia sp. PBA.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=795666 {ECO:0000313|EMBL:EIZ05032.1, ECO:0000313|Proteomes:UP000004277};
RN   [1] {ECO:0000313|EMBL:EIZ05032.1, ECO:0000313|Proteomes:UP000004277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PBA {ECO:0000313|EMBL:EIZ05032.1,
RC   ECO:0000313|Proteomes:UP000004277};
RA   Gan H.M., Yahya A.;
RT   "Draft Genome of Ralstonia sp. PBA.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled
CC       to respiration and ATP hydrolysis and functions as a proton pump
CC       across the membrane. {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- CATALYTIC ACTIVITY: NADPH + NAD(+) = NADP(+) + NADH.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EIZ05032.1}.
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DR   EMBL; AKCV01000003; EIZ05032.1; -; Genomic_DNA.
DR   RefSeq; WP_009521135.1; NZ_AKCV01000003.1.
DR   EnsemblBacteria; EIZ05032; EIZ05032; MW7_0395.
DR   PATRIC; fig|795666.3.peg.402; -.
DR   OrthoDB; POG091H0397; -.
DR   Proteomes; UP000004277; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR026255; NADP_transhyd_a.
DR   InterPro; IPR024605; NADP_transhyd_a_C.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   Pfam; PF12769; PNTB_4TM; 1.
DR   PIRSF; PIRSF000203; NADP_transhydrogenase_alpha; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00561; pntA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000004277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   NAD {ECO:0000256|PIRNR:PIRNR000203};
KW   NADP {ECO:0000256|PIRNR:PIRNR000203};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000203};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000203,
KW   ECO:0000313|EMBL:EIZ05032.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004277};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    180    203       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    438       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    444    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    469    490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    502    524       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       13    149       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      158    322       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
SQ   SEQUENCE   534 AA;  55924 MW;  E2FE10089412D84C CRC64;
     MQTTSTQPVQ RIGVPREIFP GEKRIATVPD VVEKLIKLGF TVTVESTAGE AANFSDDAYR
     AAGADIVEGA AALWAQSDIV LKVRPPSAEE VALMREGGTL ISFIWPAQNP DLMQQLAAKN
     VTVLAIDCLP RTLSRAQKMD ALTSMAGVSG YRAVVEAANA FGRYFNGQIT AAGKVPPAKV
     FIAGAGVAGL AAIGTAASLG AIVRANDTRA EVADQVKSLG GEFVKVDYEE EGSGGGGYAK
     VMSEGFQAAQ RKMYAEQAKD ADIIITTALI PGKPAPKLIT AEMVQSMKPG SVIVDMAGEQ
     GGNCELTVPG EAVVRHGVTI IGYTDLASRL AKQSSTLYAT NLLRLTEELC KAKDGHVVVN
     MEDDAIRGLT VIKDGAITWP APPLKTAPAP APKAAAPVVE KKGGHGHGST GPLPAKTLAI
     IFGVAAVLFW FIGAYAPAAF LGHFTVFVLA CFIGYMVVWN VTPALHTPLM SVTNAISSII
     AIGALVQIAP PEAGVAGRPD DLIRWLAFAA IVLTAVNMFG GFAVTRRMLD MFRK
//
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