ID IF2P_HYPBU Reviewed; 612 AA.
AC A2BJZ8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Probable translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN Name=infB {ECO:0000255|HAMAP-Rule:MF_00100}; OrderedLocusNames=Hbut_0443;
OS Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5).
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC Hyperthermus.
OX NCBI_TaxID=415426;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5456 / JCM 9403 / PLM1-5;
RX PubMed=17350933; DOI=10.1155/2007/745987;
RA Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M.,
RA She Q., Garrett R.A., Klenk H.-P.;
RT "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide
RT fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C.";
RL Archaea 2:127-135(2007).
CC -!- FUNCTION: Function in general translation initiation by promoting the
CC binding of the formylmethionine-tRNA to ribosomes. Seems to function
CC along with eIF-2. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00100}.
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DR EMBL; CP000493; ABM80309.1; -; Genomic_DNA.
DR RefSeq; WP_011821627.1; NC_008818.1.
DR AlphaFoldDB; A2BJZ8; -.
DR SMR; A2BJZ8; -.
DR STRING; 415426.Hbut_0443; -.
DR EnsemblBacteria; ABM80309; ABM80309; Hbut_0443.
DR GeneID; 4782603; -.
DR KEGG; hbu:Hbut_0443; -.
DR eggNOG; arCOG01560; Archaea.
DR HOGENOM; CLU_002656_3_3_2; -.
DR OrthoDB; 30957at2157; -.
DR Proteomes; UP000002593; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR HAMAP; MF_00100_A; IF_2_A; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR004544; TF_aIF-2_arc.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00491; aIF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis;
KW Reference proteome.
FT CHAIN 1..612
FT /note="Probable translation initiation factor IF-2"
FT /id="PRO_0000335523"
FT DOMAIN 11..229
FT /note="tr-type G"
FT REGION 20..27
FT /note="G1"
FT /evidence="ECO:0000250"
FT REGION 45..49
FT /note="G2"
FT /evidence="ECO:0000250"
FT REGION 84..87
FT /note="G3"
FT /evidence="ECO:0000250"
FT REGION 138..141
FT /note="G4"
FT /evidence="ECO:0000250"
FT REGION 207..209
FT /note="G5"
FT /evidence="ECO:0000250"
FT BINDING 20..27
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT BINDING 84..88
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT BINDING 138..141
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ SEQUENCE 612 AA; 68179 MW; 6EF671805F18400F CRC64;
MAEQKTSGRR LRQPIVVVLG HVDHGKTTLL DKIRGTTVAA KEPGLITQHV GASFVPASVI
EKLAEPLKKI IPFKLIIPGL LFIDTPGHEL FANLRRRGGS VADFAILVVD INEGFQPQTY
ESIEILRQRR VPFVVAANKI DKIPGWRANP DTPFLISLQK QAQRVREELE RRLWDNIISK
LYELGFQADR FDRIRDFTRT VAVIPISAKT GEGIAELLAV LAGLTQRYLQ HRLRFAEGPA
KGVILEIREQ PGLGTAADVV IYDGVLRKGD IIVTGGLNGP VITHVRALLM PKPLQEIRVA
KRELEPVEEV YAAAGVRIVA PGLEEAIAGA PVFVARDEGE AKQLAEKVRR EIEALRIKTE
AEGVIVKADT LGSLEAMIEA LRKRDIPIRY ADVGPVAKRD VIEAVASREL NKFYGVILAF
NVKVLPEAEE EAKKHGITIF TNNVIYRLLE DFEKWYKEQV EAERRKELEK LVRPGKIRLL
PGYVFRRSNP AIVGVEVLGG VIKPGYPLMR EDGKRIGTIH QIQDKGKVIH EARAGMAVAI
SIRGHVMVGR HIDEGDVLYT DIPEQHAVLW LTKFKSELTD DEMVVLKEII KIKRKQNPAY
AVVLGKPQGA KP
//
