LinkDB: IFNA1_CANLF
Original site: IFNA1_CANLF
Ontology (13) GO (13) Gene (66) KEGG GENES (3) NCBI-Gene (3) ENSEMBL-UP (60) Protein sequence (4) RefSeq(pep) (4) DNA sequence (2) EMBL (2) Protein domain (5) InterPro (2) Pfam (1) PROSITE (1) SMART (1) Literature (1) PubMed (1) All databases (91)
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ID IFNA1_CANLF Reviewed; 187 AA. AC P81255; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 27-MAR-2024, entry version 130. DE RecName: Full=Interferon alpha-1/2; DE Short=IFN-alpha-1/2; DE Flags: Precursor; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Liver; RX PubMed=3039013; DOI=10.1089/jir.1987.7.173; RA Himmler A., Hauptmann R., Adolf G.R., Swetly P.; RT "Structure and expression in Escherichia coli of canine interferon-alpha RT genes."; RL J. Interferon Res. 7:173-183(1987). CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. CC Interferon stimulates the production of two enzymes: a protein kinase CC and an oligoadenylate synthetase. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M28625; AAA30851.1; -; Genomic_DNA. DR EMBL; M28624; AAA30850.1; -; Genomic_DNA. DR PIR; I46204; I46204. DR RefSeq; XP_003431605.1; XM_003431557.2. DR RefSeq; XP_003431691.1; XM_003431643.2. DR RefSeq; XP_003431692.2; XM_003431644.2. DR RefSeq; XP_003431693.1; XM_003431645.2. DR AlphaFoldDB; P81255; -. DR SMR; P81255; -. DR STRING; 9615.ENSCAFP00000046622; -. DR PaxDb; 9615-ENSCAFP00000046622; -. DR Ensembl; ENSCAFT00000097701.1; ENSCAFP00000067833.1; ENSCAFG00000056067.1. DR Ensembl; ENSCAFT00000097865.1; ENSCAFP00000071563.1; ENSCAFG00000054523.1. DR Ensembl; ENSCAFT00000102044.1; ENSCAFP00000070912.1; ENSCAFG00000055920.1. DR Ensembl; ENSCAFT00000107820.1; ENSCAFP00000069314.1; ENSCAFG00000051832.1. DR Ensembl; ENSCAFT00030007122.1; ENSCAFP00030006244.1; ENSCAFG00030003837.1. DR Ensembl; ENSCAFT00030007164.1; ENSCAFP00030006278.1; ENSCAFG00030003866.1. DR Ensembl; ENSCAFT00040019783.1; ENSCAFP00040017164.1; ENSCAFG00040010698.1. DR Ensembl; ENSCAFT00040019809.1; ENSCAFP00040017187.1; ENSCAFG00040010712.1. DR Ensembl; ENSCAFT00040019849.1; ENSCAFP00040017219.1; ENSCAFG00040010740.1. DR Ensembl; ENSCAFT00805034523; ENSCAFP00805027145; ENSCAFG00805019007. DR Ensembl; ENSCAFT00805043920; ENSCAFP00805034375; ENSCAFG00805024287. DR Ensembl; ENSCAFT00805044022; ENSCAFP00805034467; ENSCAFG00805024341. DR Ensembl; ENSCAFT00805044098; ENSCAFP00805034534; ENSCAFG00805024377. DR Ensembl; ENSCAFT00805044173; ENSCAFP00805034600; ENSCAFG00805024413. DR Ensembl; ENSCAFT00805044285; ENSCAFP00805034696; ENSCAFG00805024470. DR Ensembl; ENSCAFT00805044346; ENSCAFP00805034743; ENSCAFG00805024513. DR Ensembl; ENSCAFT00805044408; ENSCAFP00805034792; ENSCAFG00805024542. DR Ensembl; ENSCAFT00805044505; ENSCAFP00805034874; ENSCAFG00805024606. DR Ensembl; ENSCAFT00845028654.1; ENSCAFP00845022551.1; ENSCAFG00845016109.1. DR Ensembl; ENSCAFT00845028742.1; ENSCAFP00845022623.1; ENSCAFG00845016171.1. DR GeneID; 100685213; -. DR GeneID; 100688005; -. DR GeneID; 100688084; -. DR KEGG; cfa:100685213; -. DR KEGG; cfa:100688005; -. DR KEGG; cfa:100688084; -. DR VEuPathDB; HostDB:ENSCAFG00845016109; -. DR VEuPathDB; HostDB:ENSCAFG00845016171; -. DR GeneTree; ENSGT01000000214430; -. DR InParanoid; P81255; -. DR OrthoDB; 5358931at2759; -. DR Proteomes; UP000002254; Chromosome 11. DR Proteomes; UP000694429; Chromosome 11. DR Proteomes; UP000694542; Unplaced. DR Proteomes; UP000805418; Chromosome 11. DR Bgee; ENSCAFG00000041836; Expressed in hypothalamus. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central. DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central. DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central. DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central. DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW. DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central. DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central. DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central. DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central. DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central. DR CDD; cd00095; IFab; 1. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR000471; Interferon_alpha/beta/delta. DR PANTHER; PTHR11691:SF60; INTERFERON ALPHA-5; 1. DR PANTHER; PTHR11691; TYPE I INTERFERON; 1. DR Pfam; PF00143; Interferon; 1. DR PRINTS; PR00266; INTERFERONAB. DR SMART; SM00076; IFabd; 1. DR SUPFAM; SSF47266; 4-helical cytokines; 1. DR PROSITE; PS00252; INTERFERON_A_B_D; 1. PE 3: Inferred from homology; KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000250" FT CHAIN 24..187 FT /note="Interferon alpha-1/2" FT /id="PRO_0000016392" FT CARBOHYD 101 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 24..122 FT /evidence="ECO:0000250" FT DISULFID 52..160 FT /evidence="ECO:0000250" SQ SEQUENCE 187 AA; 21320 MW; 3B37BA87CA47C94B CRC64; MALPCSFSVA LVLLSCHSLC CLACHLPDTH GLRNWRVLTL LGQMRRLSAG SCDHYTNDFA FPKELFDGQR LQEAQALSVV HVMTQKVFHL FCPDTSSAPW NMTLLEELCS GLSEQLDDLE ACPLQEAGLA ETPLMHEDST LRTYFQRISL YLQDRNHSPC AWEMVRAEIG RSFFSSTILQ ERIRRRK //