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Database: UniProt
Entry: IFNA1_CANLF
LinkDB: IFNA1_CANLF
Original site: IFNA1_CANLF 
ID   IFNA1_CANLF             Reviewed;         187 AA.
AC   P81255;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 130.
DE   RecName: Full=Interferon alpha-1/2;
DE            Short=IFN-alpha-1/2;
DE   Flags: Precursor;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=3039013; DOI=10.1089/jir.1987.7.173;
RA   Himmler A., Hauptmann R., Adolf G.R., Swetly P.;
RT   "Structure and expression in Escherichia coli of canine interferon-alpha
RT   genes.";
RL   J. Interferon Res. 7:173-183(1987).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; M28625; AAA30851.1; -; Genomic_DNA.
DR   EMBL; M28624; AAA30850.1; -; Genomic_DNA.
DR   PIR; I46204; I46204.
DR   RefSeq; XP_003431605.1; XM_003431557.2.
DR   RefSeq; XP_003431691.1; XM_003431643.2.
DR   RefSeq; XP_003431692.2; XM_003431644.2.
DR   RefSeq; XP_003431693.1; XM_003431645.2.
DR   AlphaFoldDB; P81255; -.
DR   SMR; P81255; -.
DR   STRING; 9615.ENSCAFP00000046622; -.
DR   PaxDb; 9615-ENSCAFP00000046622; -.
DR   Ensembl; ENSCAFT00000097701.1; ENSCAFP00000067833.1; ENSCAFG00000056067.1.
DR   Ensembl; ENSCAFT00000097865.1; ENSCAFP00000071563.1; ENSCAFG00000054523.1.
DR   Ensembl; ENSCAFT00000102044.1; ENSCAFP00000070912.1; ENSCAFG00000055920.1.
DR   Ensembl; ENSCAFT00000107820.1; ENSCAFP00000069314.1; ENSCAFG00000051832.1.
DR   Ensembl; ENSCAFT00030007122.1; ENSCAFP00030006244.1; ENSCAFG00030003837.1.
DR   Ensembl; ENSCAFT00030007164.1; ENSCAFP00030006278.1; ENSCAFG00030003866.1.
DR   Ensembl; ENSCAFT00040019783.1; ENSCAFP00040017164.1; ENSCAFG00040010698.1.
DR   Ensembl; ENSCAFT00040019809.1; ENSCAFP00040017187.1; ENSCAFG00040010712.1.
DR   Ensembl; ENSCAFT00040019849.1; ENSCAFP00040017219.1; ENSCAFG00040010740.1.
DR   Ensembl; ENSCAFT00805034523; ENSCAFP00805027145; ENSCAFG00805019007.
DR   Ensembl; ENSCAFT00805043920; ENSCAFP00805034375; ENSCAFG00805024287.
DR   Ensembl; ENSCAFT00805044022; ENSCAFP00805034467; ENSCAFG00805024341.
DR   Ensembl; ENSCAFT00805044098; ENSCAFP00805034534; ENSCAFG00805024377.
DR   Ensembl; ENSCAFT00805044173; ENSCAFP00805034600; ENSCAFG00805024413.
DR   Ensembl; ENSCAFT00805044285; ENSCAFP00805034696; ENSCAFG00805024470.
DR   Ensembl; ENSCAFT00805044346; ENSCAFP00805034743; ENSCAFG00805024513.
DR   Ensembl; ENSCAFT00805044408; ENSCAFP00805034792; ENSCAFG00805024542.
DR   Ensembl; ENSCAFT00805044505; ENSCAFP00805034874; ENSCAFG00805024606.
DR   Ensembl; ENSCAFT00845028654.1; ENSCAFP00845022551.1; ENSCAFG00845016109.1.
DR   Ensembl; ENSCAFT00845028742.1; ENSCAFP00845022623.1; ENSCAFG00845016171.1.
DR   GeneID; 100685213; -.
DR   GeneID; 100688005; -.
DR   GeneID; 100688084; -.
DR   KEGG; cfa:100685213; -.
DR   KEGG; cfa:100688005; -.
DR   KEGG; cfa:100688084; -.
DR   VEuPathDB; HostDB:ENSCAFG00845016109; -.
DR   VEuPathDB; HostDB:ENSCAFG00845016171; -.
DR   GeneTree; ENSGT01000000214430; -.
DR   InParanoid; P81255; -.
DR   OrthoDB; 5358931at2759; -.
DR   Proteomes; UP000002254; Chromosome 11.
DR   Proteomes; UP000694429; Chromosome 11.
DR   Proteomes; UP000694542; Unplaced.
DR   Proteomes; UP000805418; Chromosome 11.
DR   Bgee; ENSCAFG00000041836; Expressed in hypothalamus.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691:SF60; INTERFERON ALPHA-5; 1.
DR   PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..187
FT                   /note="Interferon alpha-1/2"
FT                   /id="PRO_0000016392"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..160
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   187 AA;  21320 MW;  3B37BA87CA47C94B CRC64;
     MALPCSFSVA LVLLSCHSLC CLACHLPDTH GLRNWRVLTL LGQMRRLSAG SCDHYTNDFA
     FPKELFDGQR LQEAQALSVV HVMTQKVFHL FCPDTSSAPW NMTLLEELCS GLSEQLDDLE
     ACPLQEAGLA ETPLMHEDST LRTYFQRISL YLQDRNHSPC AWEMVRAEIG RSFFSSTILQ
     ERIRRRK
//
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