ID IFNAH_BOVIN Reviewed; 189 AA.
AC P49878;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=Interferon alpha-H;
DE AltName: Full=IFN-alpha8;
DE Flags: Precursor;
GN Name=IFNAH; Synonyms=IFNA8;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Intestine;
RX PubMed=8662077; DOI=10.1007/bf02660063;
RA Chaplin P.J., Parsons K.R., Collins B.A.;
RT "The cloning of cattle interferon-A subtypes isolated from the gut
RT epithelium of rotavirus-infected calves.";
RL Immunogenetics 44:143-145(1996).
CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC Interferon stimulates the production of two enzymes: a protein kinase
CC and an oligoadenylate synthetase.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; X93089; CAA63638.1; -; mRNA.
DR RefSeq; NP_001165512.1; NM_001172041.1.
DR AlphaFoldDB; P49878; -.
DR SMR; P49878; -.
DR STRING; 9913.ENSBTAP00000073016; -.
DR PaxDb; 9913-ENSBTAP00000034345; -.
DR GeneID; 100329207; -.
DR KEGG; bta:100329207; -.
DR CTD; 100329207; -.
DR eggNOG; ENOG502SQAC; Eukaryota.
DR InParanoid; P49878; -.
DR OrthoDB; 5358931at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0031328; P:positive regulation of cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691:SF60; INTERFERON ALPHA-5; 1.
DR PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..189
FT /note="Interferon alpha-H"
FT /id="PRO_0000016391"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 189 AA; 21479 MW; B98F8FAC87EB5C82 CRC64;
MAPAWSFLLA LLLLSCNAIC SLGCHLPHTH SLPNRRVLTL LRQLRRVSPS SCLQDRNDFA
FPQEALGGSQ LQKAQAISVL HEVTQHTFQL FSTEGSAAAW DESLLDKLRA ALDQQLTDLQ
ACLRQEEGLR GAPLLKEDAS LAVRKYFHRL TLYLREKRHN PCAWEVVRAE VMRAFSSSTN
LQERFRRKD
//
