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Database: UniProt
Entry: IGLO5_MOUSE
LinkDB: IGLO5_MOUSE
Original site: IGLO5_MOUSE 
ID   IGLO5_MOUSE             Reviewed;         336 AA.
AC   Q8HW98; A7E1X9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   03-JUL-2019, entry version 114.
DE   RecName: Full=IgLON family member 5;
DE   Flags: Precursor;
GN   Name=Iglon5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-336.
RC   STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-336.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. IgLON
CC       family. {ECO:0000305}.
DR   EMBL; AC154108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK039193; BAC30273.1; -; mRNA.
DR   EMBL; BC116421; AAI16422.1; -; mRNA.
DR   EMBL; BC116422; AAI16423.1; -; mRNA.
DR   CCDS; CCDS52223.1; -.
DR   RefSeq; NP_001157990.1; NM_001164518.1.
DR   SMR; Q8HW98; -.
DR   STRING; 10090.ENSMUSP00000103608; -.
DR   GlyConnect; 2378; -.
DR   PhosphoSitePlus; Q8HW98; -.
DR   MaxQB; Q8HW98; -.
DR   PaxDb; Q8HW98; -.
DR   PeptideAtlas; Q8HW98; -.
DR   PRIDE; Q8HW98; -.
DR   Ensembl; ENSMUST00000107974; ENSMUSP00000103608; ENSMUSG00000013367.
DR   GeneID; 210094; -.
DR   KEGG; mmu:210094; -.
DR   UCSC; uc009gmv.2; mouse.
DR   CTD; 402665; -.
DR   MGI; MGI:2686277; Iglon5.
DR   eggNOG; ENOG410IQJC; Eukaryota.
DR   eggNOG; ENOG41102WA; LUCA.
DR   GeneTree; ENSGT00940000160467; -.
DR   HOGENOM; HOG000019085; -.
DR   InParanoid; Q8HW98; -.
DR   KO; K06773; -.
DR   OMA; AYPSPIN; -.
DR   OrthoDB; 583722at2759; -.
DR   PhylomeDB; Q8HW98; -.
DR   TreeFam; TF325565; -.
DR   PRO; PR:Q8HW98; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000013367; Expressed in 82 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; Q8HW98; baseline and differential.
DR   Genevisible; Q8HW98; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 3.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL        1     30       {ECO:0000255}.
FT   CHAIN        31    336       IgLON family member 5.
FT                                /FTId=PRO_0000332302.
FT   DOMAIN       33    122       Ig-like C2-type 1.
FT   DOMAIN      132    213       Ig-like C2-type 2.
FT   DOMAIN      218    307       Ig-like C2-type 3.
FT   CARBOHYD     41     41       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     49     49       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     67     67       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    137    137       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    288    288       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     54    112       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   DISULFID    154    195       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   DISULFID    238    291       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   CONFLICT     12     12       L -> V (in Ref. 2; BAC30273).
FT                                {ECO:0000305}.
FT   CONFLICT    199    199       N -> D (in Ref. 2; BAC30273).
FT                                {ECO:0000305}.
SQ   SEQUENCE   336 AA;  36767 MW;  FF41D4EFE02ED8A9 CRC64;
     MPPPAPGARL RLLAAAALAG LAVISRGLLS QSLEFSSPAD NYTVCEGDNA TLSCFIDEHV
     TRVAWLNRSN ILYAGNDRWT SDPRVRLLIN TPEEFSILIT QVGLGDEGLY TCSFQTRHQP
     YTTQVYLIVH VPARIVNISS PVAVNEGGNV NLLCLAVGRP EPTVTWRQLR DGFTSEGEIL
     EISDIQRGQA GEYECVTHNG VNSAPDSRRV LVTVNYPPTI TDVTSARTAL GRAALLRCEA
     MAVPPADFQW YKDDRLLSSG SAEGLKVQTE RTRSMLLFAN VSARHYGNYT CRAANRLGAS
     SASMRLLRPG SLENSAPRPP GPLTLLSALS WLWWRM
//
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