ID IKBN2_MDBVW Reviewed; 183 AA.
AC Q5I126;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=I-kappa-B like protein N2;
GN Name=N5;
OS Microplitis demolitor bracovirus (isolate Webb) (MdBV).
OC Viruses; Polydnaviriformidae; Bracoviriform;
OC Microplitis demolitor bracovirus.
OX NCBI_TaxID=654919;
OH NCBI_TaxID=69319; Microplitis demolitor (Parasitoid wasp).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16380146; DOI=10.1016/j.virol.2005.11.010;
RA Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E.,
RA Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S.,
RA Thoetkiattikul H., Turnbull M.W., Witherell R.A.;
RT "Polydnavirus genomes reflect their dual roles as mutualists and
RT pathogens.";
RL Virology 347:160-174(2006).
RN [2]
RP FUNCTION.
RX PubMed=16061795; DOI=10.1073/pnas.0505240102;
RA Thoetkiattikul H., Beck M.H., Strand M.R.;
RT "Inhibitor kappaB-like proteins from a polydnavirus inhibit NF-kappaB
RT activation and suppress the insect immune response.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:11426-11431(2005).
CC -!- FUNCTION: Suppresses the host immune response through NF-kappa-B
CC inactivation. Possesses ankyrin repeat domains required for NF-kappa-B
CC binding but lacks the regulatory regions required for dissociation from
CC NF-kappa-B and degradation. Therefore, prevents host NF-kappa-B release
CC and subsequent activation. {ECO:0000269|PubMed:16061795}.
CC -!- SIMILARITY: Belongs to the polydnaviridae I-Kappa-B like protein
CC family. {ECO:0000305}.
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DR EMBL; AY875689; AAW51806.1; -; Genomic_DNA.
DR RefSeq; YP_239402.1; NC_007039.1.
DR SMR; Q5I126; -.
DR GeneID; 5075836; -.
DR KEGG; vg:5075836; -.
DR Proteomes; UP000008168; Genome.
DR GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR PANTHER; PTHR46680:SF3; NF-KAPPA-B INHIBITOR CACTUS; 1.
DR Pfam; PF00023; Ank; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat; Host-virus interaction; Inhibition of host NF-kappa-B by virus;
KW Reference proteome; Repeat.
FT CHAIN 1..183
FT /note="I-kappa-B like protein N2"
FT /id="PRO_0000405369"
FT REPEAT 62..95
FT /note="ANK 1"
FT REPEAT 99..129
FT /note="ANK 2"
FT REGION 163..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 183 AA; 20956 MW; C1F36BDE560103CF CRC64;
MDSSDKSNLP LLLEIDWERH EAYTGENIFH VIAKKGWLKM LCALEGLVDE KIKPWLRKWS
RDGNTCLHEA ALRNKGPQAI RIMEKLIEYG ADLNLKSSCH KPVLHVAVER NDYELVAWIC
QQPGINLEAE DFYKFTAHQL ASKKNLNNDK KMVKILETYG AIPRQDGSSE DEVSDSEEKS
DSE
//
