ID IL8_CHICK Reviewed; 103 AA.
AC P08317; Q546U2;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1988, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE RecName: Full=Interleukin-8;
DE Short=IL-8;
DE AltName: Full=9E3;
DE AltName: Full=C-X-C motif chemokine 8;
DE AltName: Full=CEF-4;
DE AltName: Full=Chemokine (C-X-C motif) ligand 8;
DE AltName: Full=Embryo fibroblast protein 1;
DE Short=EMF-1;
DE Flags: Precursor;
GN Name=CXCL8; Synonyms=CEF4, EMF1, IL8;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3032449; DOI=10.1016/0092-8674(87)90284-4;
RA Sugano S., Stoeckle M.Y., Hanafusa H.;
RT "Transformation by Rous sarcoma virus induces a novel gene with homology to
RT a mitogenic platelet protein.";
RL Cell 49:321-328(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2821543; DOI=10.1073/pnas.84.19.6715;
RA Bedard P.-A., Alcorta D., Simmons D., Luk K.-C., Erikson R.L.;
RT "Constitutive expression of a gene encoding a polypeptide homologous to
RT biologically active human platelet protein in Rous sarcoma virus-
RT transformed fibroblasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:6715-6719(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10369926; DOI=10.1007/s002510050664;
RA Kaiser P., Hughes S., Bumstead N.;
RT "The chicken 9E3/CEF4 CXC chemokine is the avian orthologue of IL8 and maps
RT to chicken chromosome 4 syntenic with genes flanking the mammalian
RT chemokine cluster.";
RL Immunogenetics 49:673-684(1999).
CC -!- FUNCTION: May be an autocrine factor that promotes the growth of
CC fibroblasts and is involved in the neoplastic transformation of
CC fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear
CC cells as well as for heterophils.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- INDUCTION: By serum. Expressed constitutively in Rous sarcoma virus
CC (RSV) infected cells.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; M16199; AAA48758.1; -; mRNA.
DR EMBL; J02975; AAA49059.1; -; mRNA.
DR EMBL; AJ009800; CAB37669.1; -; Genomic_DNA.
DR PIR; A26736; A26736.
DR PIR; I50417; I50417.
DR RefSeq; NP_990829.1; NM_205498.1.
DR AlphaFoldDB; P08317; -.
DR SMR; P08317; -.
DR STRING; 9031.ENSGALP00000041738; -.
DR PaxDb; 9031-ENSGALP00000041738; -.
DR Ensembl; ENSGALT00000042745; ENSGALP00000041738; ENSGALG00000026098.
DR Ensembl; ENSGALT00010012069.1; ENSGALP00010006734.1; ENSGALG00010005131.1.
DR Ensembl; ENSGALT00015043264; ENSGALP00015025361; ENSGALG00015017670.
DR GeneID; 396495; -.
DR KEGG; gga:396495; -.
DR CTD; 396495; -.
DR VEuPathDB; HostDB:geneid_396495; -.
DR eggNOG; ENOG502S7MM; Eukaryota.
DR GeneTree; ENSGT00940000160757; -.
DR HOGENOM; CLU_143902_3_0_1; -.
DR InParanoid; P08317; -.
DR OMA; EKMLNCD; -.
DR OrthoDB; 5343536at2759; -.
DR PhylomeDB; P08317; -.
DR TreeFam; TF333433; -.
DR Reactome; R-GGA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-GGA-418594; G alpha (i) signalling events.
DR PRO; PR:P08317; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000026098; Expressed in granulocyte and 6 other cell types or tissues.
DR ExpressionAtlas; P08317; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; NAS:AgBase.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; IMP:AgBase.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0030097; P:hemopoiesis; TAS:AgBase.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0002269; P:leukocyte activation involved in inflammatory response; TAS:AgBase.
DR GO; GO:0030595; P:leukocyte chemotaxis; TAS:AgBase.
DR GO; GO:0002232; P:leukocyte chemotaxis involved in inflammatory response; TAS:AgBase.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IDA:AgBase.
DR GO; GO:0048246; P:macrophage chemotaxis; IDA:AgBase.
DR GO; GO:0002548; P:monocyte chemotaxis; IDA:AgBase.
DR GO; GO:0036446; P:myofibroblast differentiation; IDA:AgBase.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; IDA:AgBase.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR GO; GO:0050729; P:positive regulation of inflammatory response; TAS:AgBase.
DR GO; GO:0042060; P:wound healing; IDA:AgBase.
DR CDD; cd00273; Chemokine_CXC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF204; C-X-C MOTIF CHEMOKINE 15; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00436; INTERLEUKIN8.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Disulfide bond; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..103
FT /note="Interleukin-8"
FT /id="PRO_0000005138"
FT DISULFID 33..60
FT /evidence="ECO:0000250"
FT DISULFID 35..76
FT /evidence="ECO:0000250"
FT CONFLICT 5
FT /note="L -> F (in Ref. 2; AAA49059)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 103 AA; 11056 MW; 28A9802A22349A6F CRC64;
MNGKLGAVLA LLLVSAALSQ GRTLVKMGNE LRCQCISTHS KFIHPKSIQD VKLTPSGPHC
KNVEIIATLK DGREVCLDPT APWVQLIVKA LMAKAQLNSD APL
//
