ID IML1_CRYNJ Reviewed; 1768 AA.
AC P0CO32; Q55V51; Q5KL31;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Vacuolar membrane-associated protein IML1;
GN Name=IML1; OrderedLocusNames=CNC00940;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR EMBL; AE017343; AAW42101.1; -; Genomic_DNA.
DR RefSeq; XP_569408.1; XM_569408.1.
DR AlphaFoldDB; P0CO32; -.
DR STRING; 214684.P0CO32; -.
DR PaxDb; 214684-P0CO32; -.
DR EnsemblFungi; AAW42101; AAW42101; CNC00940.
DR eggNOG; KOG3572; Eukaryota.
DR HOGENOM; CLU_000935_1_0_1; -.
DR InParanoid; P0CO32; -.
DR OMA; SWMNATP; -.
DR Proteomes; UP000002149; Chromosome 3.
DR GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR CDD; cd04449; DEP_DEPDC5-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR048255; IML1_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Vacuole.
FT CHAIN 1..1768
FT /note="Vacuolar membrane-associated protein IML1"
FT /id="PRO_0000301770"
FT DOMAIN 1326..1402
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 86..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1729..1768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..893
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1768 AA; 197541 MW; 16B1F4BE31D4A0CD CRC64;
MEGGVLDLSL LNKDRDNVAL LLYTYKPLLN NTGASANPAH PSLLPSAAAS PNAPSSQVII
NYAALPWNVQ PGDYLEIRQI NRTQPKVPTA STRIQGMEGE KPQKIKRPPA LEDVKTGKGR
EGYVFRLGED SPTANIHQIQ VPDSVATAFG FQNRLEVEVR RIHDKESSHA DYIEFYFSQY
LGRADMWRLG MSLEGTTLHV GEKVSLAGGA VRAEVNFIIR DEKSKDGIAK PKRYSSGIVT
AKTKTIFRSK SAQVYLFIQL CEETWQFDED GERYVEKVVH GYLPELFARW ADKGTSHVVT
IIFFARIFYR DDEVDYLRKH DMVDMLSQDY SGQWYKDFFK VAVDLERRND WMSSLPEIKR
QLERSEREIL LDYHLRLLKA KGAAEEEIKI VGKWCFAYQG NVLEAINLAL NPFDEHYVDR
DLSRTGLSIT VVTPGTGHFA VDKNLLRLTT ERMVDHGMSV DFVCLTKMPL HSVPLFSYVS
HRPKGPVQHE DGIGAKAKPV VPDLLYFDAN LSQVKDIELA DCYSLPSWVS TSFYAVTHDK
PFREDRFVAR CKMYDIQMLG ILDHNLTTVT VPLLNVDDTP MPRRPLTVDD RKAIRDSFDQ
SIFSGISDLV KTGSSPLDSA PASVTASYQS ARLLAEKAKE RTSSMSLSKP RGSDIANSSR
LSPIKATSES DNIDLGKKTT PRSPSPEPSS LSLRRGSRRS LSPTKMTQLA HTSAVTNELN
KDSPSLLKNS RPGSPITMAR SISPVPPLPP TREQGDSPLS PVDSLPLSAS VERSPSPSRR
SVRSNMTDRE HLGSGASTPK GTPAKSLRSQ PSKGFIPSWV LNSFKPLLST SKPSFAVPAM
ENVARTDVAT GDDNRPSSPS PSVGSLRGRP SKGGPNPKPI ITPSTPSPSR SQKPPFKPAK
IIQTQPHTQA QGTQPLPIAA PPASRLPSQS EEDAISRSFR NKGHGLSRSH EDSSLRAQSN
ALVQSSRHFT INPCKPSAET IDRVRDAGGR RWRFVLPKLT QQHIVQWPSL IAPACLPLTT
DFLPDQKQSD ELYTTGTYTV QCYLEDDQFL IRSDAAETNL ALAMMREMVS QRLSQNFQVI
VQPHELTEPE KPRPMPIHLE KDADIGVELV SGGASEVLKK GQGAIWLSWA NHIHRLLFHP
TKPEIVVHWM TRKITHQTES VQWKGLVWPS GMKGYQKASA TFAYPDVSMK INYNHLDHLI
NGERIDFAPL RYWRTRFILI PSGREPVTFP GLMPKNENLG SNDLLWLGAQ KVMETLNRYL
LKRPEGTPQQ RSLKIVATTF DPSTCVLDEE LMMDLARQIH GDSSGDKKKK LEGMTLANVA
ELMCQPDNGL VIRTRWWESR QHVSSFNGFE LREWLQNTFE DVTGREKAQE WAAELTNKGL
IEHVTKSHGF LDYWHLYYRL REPYNHMYSH LAKKEGKNKS WFSTSSKGSR AAPPSLTSSQ
ASSSTVIAAA VADPSQATAD LNTSQSGKDP SAGEQDQSSL AKIYLKVHKG EPKQGGKKRK
IMMTQKRVLD LDPSRKSDRA EVAILHADVV HNARNAFHFE LNWLGVTAAL LEELRQKLSA
QSERYGLRFV ETPVEQIADI PKKCAYRTPI PIRLALAPPV IPDLHTRLVA VAHGTGQAEN
YFEYSILTKK FGFVLDVEAT DRYPDNVEVV YSYRKAGVKY TYSQFCHKTG LALVQCVGGE
AGFLWSDNRL VVSAPTRKGV GNRVDEARAL RKELEDFCSD AEQLSKFYEE VLPPPPTTGE
STPEEGQEEF EAKDDEEEQP APQEKTEL
//
