ID IPIL2_HUMAN Reviewed; 535 AA.
AC Q3MIP1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2;
DE Flags: Precursor;
GN Name=ITPRIPL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the ITPRIP family. {ECO:0000305}.
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DR EMBL; CH471186; EAW50272.1; -; Genomic_DNA.
DR EMBL; BC101749; AAI01750.1; -; mRNA.
DR EMBL; BC101751; AAI01752.1; -; mRNA.
DR CCDS; CCDS32395.1; -.
DR RefSeq; NP_001030013.1; NM_001034841.3.
DR AlphaFoldDB; Q3MIP1; -.
DR BioGRID; 127808; 33.
DR IntAct; Q3MIP1; 6.
DR STRING; 9606.ENSP00000370849; -.
DR iPTMnet; Q3MIP1; -.
DR PhosphoSitePlus; Q3MIP1; -.
DR BioMuta; ITPRIPL2; -.
DR DMDM; 121942822; -.
DR EPD; Q3MIP1; -.
DR jPOST; Q3MIP1; -.
DR MassIVE; Q3MIP1; -.
DR PaxDb; 9606-ENSP00000370849; -.
DR PeptideAtlas; Q3MIP1; -.
DR ProteomicsDB; 61790; -.
DR Antibodypedia; 62727; 42 antibodies from 11 providers.
DR DNASU; 162073; -.
DR Ensembl; ENST00000381440.5; ENSP00000370849.3; ENSG00000205730.7.
DR GeneID; 162073; -.
DR KEGG; hsa:162073; -.
DR MANE-Select; ENST00000381440.5; ENSP00000370849.3; NM_001034841.4; NP_001030013.1.
DR UCSC; uc002dfu.5; human.
DR AGR; HGNC:27257; -.
DR CTD; 162073; -.
DR GeneCards; ITPRIPL2; -.
DR HGNC; HGNC:27257; ITPRIPL2.
DR HPA; ENSG00000205730; Low tissue specificity.
DR neXtProt; NX_Q3MIP1; -.
DR OpenTargets; ENSG00000205730; -.
DR PharmGKB; PA164721117; -.
DR VEuPathDB; HostDB:ENSG00000205730; -.
DR eggNOG; ENOG502QT2J; Eukaryota.
DR GeneTree; ENSGT01050000244827; -.
DR HOGENOM; CLU_043756_0_0_1; -.
DR InParanoid; Q3MIP1; -.
DR OMA; RVYGGPR; -.
DR OrthoDB; 5345953at2759; -.
DR PhylomeDB; Q3MIP1; -.
DR TreeFam; TF332277; -.
DR PathwayCommons; Q3MIP1; -.
DR SignaLink; Q3MIP1; -.
DR BioGRID-ORCS; 162073; 11 hits in 1149 CRISPR screens.
DR ChiTaRS; ITPRIPL2; human.
DR GenomeRNAi; 162073; -.
DR Pharos; Q3MIP1; Tdark.
DR PRO; PR:Q3MIP1; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q3MIP1; Protein.
DR Bgee; ENSG00000205730; Expressed in tendon of biceps brachii and 191 other cell types or tissues.
DR Genevisible; Q3MIP1; HS.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.1410.40; -; 1.
DR Gene3D; 3.30.460.90; -; 1.
DR InterPro; IPR026250; ITPRIP-like.
DR InterPro; IPR024810; Mab-21-like.
DR InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR PANTHER; PTHR10656:SF9; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 2; 1.
DR Pfam; PF20266; Mab-21_C; 1.
DR PRINTS; PR02107; INOS145TPRIP.
DR SMART; SM01265; Mab-21; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..535
FT /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT protein-like 2"
FT /id="PRO_0000336093"
FT TOPO_DOM 39..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..535
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 139
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VARIANT 237
FT /note="C -> S (in dbSNP:rs8051801)"
FT /id="VAR_043549"
FT VARIANT 522
FT /note="P -> S (in dbSNP:rs11074362)"
FT /id="VAR_043550"
SQ SEQUENCE 535 AA; 58446 MW; 000E9D653FD16284 CRC64;
MSVHYTLNLR VFWPLVTGLC TALVCLYHVL RGSGGARAEP ADGVDGGFPL LKVAVLLLLS
YVLLRCRHAV RQRFLPGSPR LEGHAAFSSR HFREPGLSIL LESYYEHEVR LSPHVLGHSK
AHVSRIVGEL VRAGRARGSP GLIPGGALAL AFRGDFIQVG SAYEQHKIRR PDSFDVLVPL
RLPPLVALEP RSLGEEPALA PAFRGCFLCA LKAPPSPSGA SGGHWLRDCK PFADAFCVDV
RGRRHLSATL VLRWFQSHLQ RSLATVRYSL EGRCRVTLTP GGLEQPPTLH ILPCRTDYGC
CRLSMAVRLI PAVHLGDGVF LVAPPPPPLP SAPLLELPEG LRAEALWGVN TARQEQKLLS
WLQERAAPGA CYLKCLQLLK ALRDLGARGL DSAAATQWGR ILSSYVLKTV LLAVLLRKGA
PGQGWDEEHL GRCLEELVQF LRDCLLRRHT LFHCVLGPGG AAAEVGPLPK ALREAAPVDL
LAAFDGHARE LAAARLLSTW QRLPQLLRAY GGPRYLARCP PPRSQRTQGF LEGEP
//
