ID   J0D4Z4_9BIFI            Unreviewed;       583 AA.
AC   J0D4Z4;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Hydroxymethylglutaryl-CoA reductase, degradative {ECO:0000313|EMBL:EJD65020.1};
GN   ORFNames=HMPREF9156_00464 {ECO:0000313|EMBL:EJD65020.1};
OS   Scardovia wiggsiae F0424.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Scardovia.
OX   NCBI_TaxID=857290 {ECO:0000313|EMBL:EJD65020.1, ECO:0000313|Proteomes:UP000006415};
RN   [1] {ECO:0000313|EMBL:EJD65020.1, ECO:0000313|Proteomes:UP000006415}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0424 {ECO:0000313|EMBL:EJD65020.1,
RC   ECO:0000313|Proteomes:UP000006415};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Ganesan A.,
RA   Baranova O.V., Blanton J.M., Tanner A.C., Mathney J., Dewhirst F.E.,
RA   Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA   Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Gearin G.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D., Howarth C.,
RA   Larimer J., Lui A., MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Scardovia wiggsiae F0424.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC       {ECO:0000256|ARBA:ARBA00007661}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJD65020.1}.
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DR   EMBL; AGZS01000002; EJD65020.1; -; Genomic_DNA.
DR   RefSeq; WP_007147531.1; NZ_JH719939.1.
DR   AlphaFoldDB; J0D4Z4; -.
DR   STRING; 857290.HMPREF9156_00464; -.
DR   GeneID; 84815395; -.
DR   eggNOG; COG1257; Bacteria.
DR   HOGENOM; CLU_033422_0_0_11; -.
DR   OrthoDB; 9764892at2; -.
DR   Proteomes; UP000006415; Unassembled WGS sequence.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR   Gene3D; 1.10.8.660; -; 1.
DR   InterPro; IPR002202; HMG_CoA_Rdtase.
DR   InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR   InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR   InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR   InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR   PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   Pfam; PF00368; HMG-CoA_red; 2.
DR   SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR   SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006415}.
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   583 AA;  60648 MW;  9EA0531786B1492B CRC64;
     MCRQEQPDNQ AQHGEQAVRR ERREPVFRGG SEEREVREVH GDGETGSGCA VRELREMRGS
     KFYRLSPQGR LQVLMQEGVI TAEDMQEIAG FTGLDADAAR NLIENQIGQF ALPMGIVRNL
     EVNGKIYQVP VVTEEPSVVA AASNGARIAR ANGGVAAQAG SHCVTGEIIF SCGSSSGDAG
     VIDAGEGYAG SGANSCGAAG DARGGIEAAR IARILETHSD DIRTVANAAH PSIVGYGGGL
     LSYKVEILGG DVPAAYSSPM PKEGESAGRE GLAGREDPGG SLNGSRPGSS CRPSGCNSCK
     PYDCSSCRPE GFVKLSLIID PCDAMGANIV NTICEAVAAA AEGWTGYRAL TAILSNNVPA
     ASAASARVEV QPHTLATRSC SGELIARRIA ELSALARIDT DRAVTHNKGI MNGISSAVLA
     SGNDTRAVEA GAHAFAARTG CYMPLSEWVL NSRGNLYGEI RIPLQVGIIG GASGALPMAR
     LAKKIGGYPS VQEFQCVLAS LGLVQNLAAL RALAGPGIQQ GHMALHANAL AMAAGARGSE
     IEQVSRILQG RDKNLETAVE ILADIRGSRR PEESEEPEEG GIR
//