ID J0MVV3_9ACTO Unreviewed; 674 AA.
AC J0MVV3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Proton-translocating NADH-quinone oxidoreductase, chain L {ECO:0000313|EMBL:EJF36182.1};
DE EC=1.6.-.- {ECO:0000313|EMBL:EJF36182.1};
GN ORFNames=HMPREF1318_0468 {ECO:0000313|EMBL:EJF36182.1};
OS Actinomyces massiliensis F0489.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=1125718 {ECO:0000313|EMBL:EJF36182.1, ECO:0000313|Proteomes:UP000002941};
RN [1] {ECO:0000313|EMBL:EJF36182.1, ECO:0000313|Proteomes:UP000002941}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0489 {ECO:0000313|EMBL:EJF36182.1,
RC ECO:0000313|Proteomes:UP000002941};
RA Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Nelson K.E.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJF36182.1}.
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DR EMBL; AKFT01000224; EJF36182.1; -; Genomic_DNA.
DR RefSeq; WP_008734080.1; NZ_AKFT01000224.1.
DR AlphaFoldDB; J0MVV3; -.
DR PATRIC; fig|1125718.3.peg.2872; -.
DR eggNOG; COG1009; Bacteria.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000002941; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR Gene3D; 1.20.5.2700; -; 1.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR NCBIfam; TIGR01974; NDH_I_L; 1.
DR PANTHER; PTHR42829; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR PANTHER; PTHR42829:SF2; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
DR PRINTS; PR01435; NPOXDRDTASE5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:EJF36182.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002941};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..147
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 165..453
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 674 AA; 71126 MW; F66CE3668EA684EE CRC64;
MTASSLVLAG AIGHGAAAPT PLVGPATGLA SMAWLLIAVP AAGAAILLLA GRVSDRWGHL
LGLLASLASA CLGLGILAQV LGLPAEERTM VVSLWRWFGA GDLDVRIGLR IDPLSLTFVA
LVTFVGFLIH VYSVAYMAHD RNRRRFFAYL NLFIAAMLTL VLGDSYIVLF VGWEGVGLAS
YLLIGFWNTA DADAPQAERF TSRQNATAAK KAFIMNRIGD VGLLLAMMAM VSQVGSVSFL
SVLPAAQYGA LSTGWLTAIG FFLLLAACGK SAQFPLQAWL GDAMAGPTPV SALIHAATMV
TAGVYLMVRS GAIFESAPGA QLAVAVIGAI TLVLGAVIGS AKDDMKKVLA ASTMSQIGYM
MLGAGLGPIG YAFAIFHLLT HGFFKAQLFL GAGSVMHAMS DQVDMRRFGA LAKVMRITWI
TMAIGWLAIL GIPPFSGFWS KDRIIEAAFV GEGARPWILG TIALLGAGLT AFYMSRLFFM
IFHGRARWTT EKDIEGAVHP HESSWLMTLP LIILSVFSLG LGGLLSMNDV FVTWLEPVTG
HAEHGEPVLP ATVIMGATLA LVLIGVVVAW FMYARRPVPT VVQTGSALVR AARNDMYQDV
INEGLAMRPG QGLVIAAAAS DRYVVDGAVE GLAKGAAGAG QLVRRTESGY VRSYAGYMLA
GTVLALIAVL ASRF
//
