ID J0S4C3_9FLAO Unreviewed; 640 AA.
AC J0S4C3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN ORFNames=FF52_01870 {ECO:0000313|EMBL:EJG02900.1};
OS Flavobacterium sp. F52.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1202532 {ECO:0000313|EMBL:EJG02900.1, ECO:0000313|Proteomes:UP000002690};
RN [1] {ECO:0000313|EMBL:EJG02900.1, ECO:0000313|Proteomes:UP000002690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F52 {ECO:0000313|EMBL:EJG02900.1,
RC ECO:0000313|Proteomes:UP000002690};
RX PubMed=22965088; DOI=10.1128/JB.01249-12;
RA Kolton M., Green S.J., Harel Y.M., Sela N., Elad Y., Cytryn E.;
RT "Draft Genome Sequence of Flavobacterium sp. Strain F52, Isolated from the
RT Rhizosphere of Bell Pepper (Capsicum annuum L. cv. Maccabi).";
RL J. Bacteriol. 194:5462-5463(2012).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000256|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01810}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527, ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJG02900.1}.
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DR EMBL; AKZQ01000006; EJG02900.1; -; Genomic_DNA.
DR RefSeq; WP_008462488.1; NZ_AKZQ01000006.1.
DR AlphaFoldDB; J0S4C3; -.
DR PATRIC; fig|1202532.3.peg.389; -.
DR eggNOG; COG0706; Bacteria.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000002690; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR CDD; cd19961; EcYidC-like_peri; 1.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR NCBIfam; TIGR03593; yidC_nterm; 1.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01810};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01810};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01810}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 443..466
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 508..526
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 547..566
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT DOMAIN 100..371
FT /note="Membrane insertase YidC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14849"
FT DOMAIN 387..589
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 603..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 72808 MW; 2F6FA25C497A2819 CRC64;
MEEKKLDLNS IIGFVLIFGI LIWIMYQNQP SEKEIAAEKA KKELVAKQEA QAKADKAKTA
SLPAAAVTPG DTVQLVQLQK TLGGFAYSAT LPSAKEAFTT IENEKLRLKI ANKGGYIVEA
TLKEFERLKK GSGQLVELIK NNNSNLNLQL LTTDNRTLNS KDLYFEPTLE KIGADQVLSM
RLKAGANEFL EYKYILKPND YLVGFDIRSQ GLNRVLNSAK PVDLQWDLKT YRNEKSVAYE
NRYAQIDYKY EESKYNNVSS HGQGKEETPT KVSYVAFKQH FFTTILSTEK PFETSKLQSD
DLVKDDKIDT VFTKQFRANL PLAFTNGEID YKMNLYMGPA DYKTLKAYDK NFEKIIPLGW
GIFGWINKWI FIPLFGFLSS TIGLSLGIAI IIFTIIIKLA MSPITYKSFL SQAKMKVLRP
DIAELGEKFK KDPMKKQQET MKLYNKAGVN PMAGCIPALI QLPFMYASFQ FFPAAFELRQ
KSFLWADDLS SFDSIVKLPF NIPMYGDHIS LFPILAAIAI FFYMKMTSGD QQMAAPQQEG
MPDMAKMMKI MIYVSPLMML IFFNNYGSGL SLYNFISNLI TIGIMFVIKN YIVDSDKIHA
QIQENKQREP KKPSKFQQRL QEVMEQQEAA KAAQANKKKK
//
