ID J0X145_9BIFI Unreviewed; 441 AA.
AC J0X145;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=UmuC domain-containing protein {ECO:0000259|PROSITE:PS50173};
GN ORFNames=HMPREF9156_00323 {ECO:0000313|EMBL:EJD65559.1};
OS Scardovia wiggsiae F0424.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Scardovia.
OX NCBI_TaxID=857290 {ECO:0000313|EMBL:EJD65559.1, ECO:0000313|Proteomes:UP000006415};
RN [1] {ECO:0000313|EMBL:EJD65559.1, ECO:0000313|Proteomes:UP000006415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0424 {ECO:0000313|EMBL:EJD65559.1,
RC ECO:0000313|Proteomes:UP000006415};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Ganesan A.,
RA Baranova O.V., Blanton J.M., Tanner A.C., Mathney J., Dewhirst F.E.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Gearin G.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D., Howarth C.,
RA Larimer J., Lui A., MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Scardovia wiggsiae F0424.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJD65559.1}.
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DR EMBL; AGZS01000001; EJD65559.1; -; Genomic_DNA.
DR RefSeq; WP_007147391.1; NZ_JH719939.1.
DR AlphaFoldDB; J0X145; -.
DR STRING; 857290.HMPREF9156_00323; -.
DR GeneID; 84815258; -.
DR eggNOG; COG0389; Bacteria.
DR HOGENOM; CLU_012348_3_0_11; -.
DR OrthoDB; 9808813at2; -.
DR Proteomes; UP000006415; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd01700; PolY_Pol_V_umuC; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025188; DUF4113.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11076:SF34; PROTEIN UMUC; 1.
DR Pfam; PF13438; DUF4113; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00023199};
KW Reference proteome {ECO:0000313|Proteomes:UP000006415};
KW SOS mutagenesis {ECO:0000256|ARBA:ARBA00023199};
KW SOS response {ECO:0000256|ARBA:ARBA00023236}.
FT DOMAIN 9..191
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 441 AA; 47940 MW; 718BF352B3663A1C CRC64;
MACNRYNSVI LADANSFFAS CERVFDPSLN GKPIVVLSNN DGCVVARSSE ARALGIGMCT
PWFAIKEDAA RKGVIARSSN YELYASLSHR MMSVMRSFFP GQEVYSIDEC FLTNPCTDDA
ASISTCIRMR KAILQGIGIP VSIGIAPTKT LAKIVNHWAK SHPATHGVLS WSQVSADILQ
RTPVSDVWGV GRHLSSKLMS HDILTAADLG NSDPETIRHQ YSISVERTVL ELRGIPCIPE
ENTDDTVEGA RKAQIMYSRM FGQPVRGYST LCQALSVYAQ KAAHRLKRQG SLCGAVSIFC
ATGHRRHSRS TSSHAWNTCI LDSPTDNPIT ISQAACETAR TVVDPDACYA RAGITLHKLV
SKSSYNLLDA DTPLKGTEKL GNTLDLITGR FGPMSAGIGY GGIRGTGRYS SDTGSPWAMK
RTMLSKRCTT RWSEMAVVKA D
//
