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Database: UniProt
Entry: J1HE25_9ACTO
LinkDB: J1HE25_9ACTO
Original site: J1HE25_9ACTO 
ID   J1HE25_9ACTO            Unreviewed;       318 AA.
AC   J1HE25;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   10-APR-2019, entry version 30.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=HMPREF1318_1042 {ECO:0000313|EMBL:EJF43653.1};
OS   Actinomyces massiliensis F0489.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=1125718 {ECO:0000313|EMBL:EJF43653.1, ECO:0000313|Proteomes:UP000002941};
RN   [1] {ECO:0000313|EMBL:EJF43653.1, ECO:0000313|Proteomes:UP000002941}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0489 {ECO:0000313|EMBL:EJF43653.1,
RC   ECO:0000313|Proteomes:UP000002941};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B.,
RA   Sutton G.G., Nelson K.E.;
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJF43653.1}.
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DR   EMBL; AKFT01000120; EJF43653.1; -; Genomic_DNA.
DR   RefSeq; WP_008731781.1; NZ_AKFT01000120.1.
DR   STRING; 1125718.HMPREF1318_1042; -.
DR   EnsemblBacteria; EJF43653; EJF43653; HMPREF1318_1042.
DR   PATRIC; fig|1125718.3.peg.1608; -.
DR   BioCyc; GCF_000296275-HMP:HMPREF1318_RS07890-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000002941; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002941};
KW   Lyase {ECO:0000256|RuleBase:RU361254, ECO:0000313|EMBL:EJF43653.1};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002941}.
FT   DOMAIN        6    192       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      207    284       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        185    185       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   318 AA;  33600 MW;  945881697BA02793 CRC64;
     MNPAPTWSFL GPSGTFCEMA LRQVAPDDVV LDSCQDVPTA LDRVRDRAAE AAVVPIENSV
     EGGVNATLDN LVAGAPLVIT AEMAVPITFV LAGRPGVALD DVRAISTHPH AWAQCRGWVH
     QHLPEASYVA GTSTSAPARA LAEADGAADA EALGYQAVLC NPLAAQQYGL DVLAGGVADN
     PDAVTRFVKV ARPGRVGEPT GADKTTLLVQ LSHNRSGALL SMLEQFSARG VNLTRIESRP
     VGDSLGRYRF SIDAEGHIRE ERLQAAFIGL HRTCPVVRFL GSYPRLDARP VVVPAGTSDK
     DFVVARAWVG DVLAGRTL
//
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