ID J1L4K7_9EURY Unreviewed; 769 AA.
AC J1L4K7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Efflux transporter, hydrophobe/amphiphile efflux-3 (HAE3) family {ECO:0000313|EMBL:EJG08047.1};
GN ORFNames=Metli_2106 {ECO:0000313|EMBL:EJG08047.1};
OS Methanofollis liminatans DSM 4140.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanofollis.
OX NCBI_TaxID=28892 {ECO:0000313|EMBL:EJG08047.1};
RN [1] {ECO:0000313|EMBL:EJG08047.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4140 {ECO:0000313|EMBL:EJG08047.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Lu M., Detter J.C.,
RA Tapia R., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Spring S., Schuler E., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanofollis liminatans DSM 4140.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CM001555; EJG08047.1; -; Genomic_DNA.
DR RefSeq; WP_004040212.1; NZ_CM001555.1.
DR AlphaFoldDB; J1L4K7; -.
DR STRING; 28892.Metli_2106; -.
DR HOGENOM; CLU_008861_2_0_2; -.
DR OrthoDB; 42357at2157; -.
DR Proteomes; UP000005095; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00921; 2A067; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..354
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 605..751
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 769 AA; 82682 MW; 6505B8EBBD11C717 CRC64;
MKTPYERLAD AINAHTAVVF GVAMAVFLIA LFGLSMVTME TGDDTYIDKD TPRGALLSHY
KDTYGSDAIM LIFECDDVTD PAVLKYIDRL EETIRRERYI DSASGITDMM KQINGGVLPS
SVAEVSAIKS AIPAATLERY LPSSMMTITG VTLEPGIQST VQQQVLDNIR TIISISSPPP
GLTVTVSGTP AFSQEMGQEM GSSMGILIMA AMLLMLLAVS TLFSHVRYRL LPVAIVAVGV
ILTFGLMGLF GIPISMTVIG AFPVLIGIGI DYAIQFHTRF DEEMQHGTIP QAVKATVANS
GPSVLIAMLA TSLGFIAMFL APIPMIADFG VTCVIGVVCC YLSALIIVPL FGIITKYRVK
EKTGVLDDVA ACELDWKGCE TEPFHKKGSR GSLTEHYNRA LGSVALKIAK NPVPVLLIFG
LVALVGFQMD TRVPVNADQD TFVPSDMPAL LDMEKVTRTM GSTTSIPVMV TGDDVLSADT
LKWIDGFATY ELERNDKITG ASSIVTLIKQ YNNGVIPDTE AGVRDVLSTI PEDSKGRYLN
GNMEAAILFS TVDMEMDTAR SMIENLVKEA AWYPAPPGTT VRVTGSTEMF AALMDDITNS
KTTMVIAGFV LILGFLLLVY RKFNAVTPLI PIVMIVGWNG AIMYLLGLDY TPMTATLGSM
TIGVASEYTI LIMERCEEEL ARGLNIYEAI QTAVQKIGMA ITVSGMTTVF GFSALTLSAF
NIISNFGIVT VITVGFSLVG AILVMPAVLA VMYRFSHPHA VNAAEIPAA
//
