ID J1RU86_9ACTN Unreviewed; 446 AA.
AC J1RU86;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Insulinase family protein {ECO:0000313|EMBL:QTZ96367.1};
DE SubName: Full=Zinc protease {ECO:0000313|EMBL:EJJ08079.1};
GN ORFNames=SU9_026235 {ECO:0000313|EMBL:QTZ96367.1}, SU9_05356
GN {ECO:0000313|EMBL:EJJ08079.1};
OS Streptomyces auratus AGR0001.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1160718 {ECO:0000313|EMBL:EJJ08079.1};
RN [1] {ECO:0000313|EMBL:EJJ08079.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGR0001 {ECO:0000313|EMBL:EJJ08079.1};
RX PubMed=22965094; DOI=10.1128/JB.01155-12;
RA Han X., Li M., Ding Z., Zhao J., Ji K., Wen M., Lu T.;
RT "Genome Sequence of Streptomyces auratus Strain AGR0001, a Phoslactomycin-
RT Producing Actinomycete.";
RL J. Bacteriol. 194:5472-5473(2012).
RN [2] {ECO:0000313|EMBL:QTZ96367.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AGR0001 {ECO:0000313|EMBL:QTZ96367.1};
RA Wen M.-L., Han X.-L., Xiong J.;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; AJGV01000042; EJJ08079.1; -; Genomic_DNA.
DR EMBL; CP072931; QTZ96367.1; -; Genomic_DNA.
DR RefSeq; WP_006602650.1; NZ_CP072931.1.
DR AlphaFoldDB; J1RU86; -.
DR STRING; 1160718.SU9_05356; -.
DR KEGG; sauh:SU9_026235; -.
DR PATRIC; fig|1160718.3.peg.1101; -.
DR eggNOG; COG0612; Bacteria.
DR HOGENOM; CLU_009902_1_1_11; -.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000009036; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR PANTHER; PTHR43690:SF17; PROTEIN YHJJ; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:EJJ08079.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009036};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 26..166
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 185..364
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 446 AA; 48675 MW; 7B9CA53D71752F8F CRC64;
MGHTATEQAG SGGLTATEHR LANGLRVVLS EDHLTPVAAV CLWYDVGSRH EVEGRTGLAH
LFEHLMFQGS AQVTGNGHFE LVQGAGGSLN GTTSFERTNY FETMPAHELE LALWLEADRM
GSLLTALDDE SMENQRDVVK NERRQRYDNV PYGTAFEKLT AMAYPEGHPY HHTPIGSMAD
LDAASLEDAR AFFRTYYAPS NAVLSVVGDI DPEQTLAWVE KYFGSIPSHD GKQPPRDGTL
PDVIGGQLRE VVEEDVPARA LMAAYRLPHD GTREADAADL ALTVLGGGES SRLYNRLVRR
DRSAVAAGFG LLRLAGAPSL GWLDVKTSGG VEVPSIERAV DEELARFAAE GPTPEEMERA
QAQLEREWLD RLATVSGRAD ELCRFAVLFG DPQLALSAVQ RVLDITPEEV QAVAKARLRP
DNRAVLVYEP TEQNDAADTE EGQADQ
//
