ID   J1RV89_9ACTN            Unreviewed;       882 AA.
AC   J1RV89;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:EJJ02442.1};
GN   ORFNames=SU9_33893 {ECO:0000313|EMBL:EJJ02442.1};
OS   Streptomyces auratus AGR0001.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1160718 {ECO:0000313|EMBL:EJJ02442.1};
RN   [1] {ECO:0000313|EMBL:EJJ02442.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AGR0001 {ECO:0000313|EMBL:EJJ02442.1};
RX   PubMed=22965094; DOI=10.1128/JB.01155-12;
RA   Han X., Li M., Ding Z., Zhao J., Ji K., Wen M., Lu T.;
RT   "Genome Sequence of Streptomyces auratus Strain AGR0001, a Phoslactomycin-
RT   Producing Actinomycete.";
RL   J. Bacteriol. 194:5472-5473(2012).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJJ02442.1}.
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DR   EMBL; AJGV01000231; EJJ02442.1; -; Genomic_DNA.
DR   AlphaFoldDB; J1RV89; -.
DR   STRING; 1160718.SU9_33893; -.
DR   PATRIC; fig|1160718.3.peg.6858; -.
DR   eggNOG; COG1028; Bacteria.
DR   eggNOG; COG3321; Bacteria.
DR   HOGENOM; CLU_000022_35_2_11; -.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 6.10.140.1830; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF18369; PKS_DE; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          726..801
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   882 AA;  93962 MW;  71BF182A6B3CA314 CRC64;
     MESIEETLRE VLAPVAPRKS SVPLFSTVTG EWLDTAEMDA GYWFTNLRRT VEFAPAIEAL
     VAAGHRTFVE VSPHPVLTVP LQETVESVGA DAVVTGTLRR DDGGLSRLYT SLGELYVHGV
     EVDWSPAFAA ARPQLVDLPT YAFQHRRYWL ESGRSSVAGA VDPVDVRFWE SVEREGVDGL
     AATLGLADPG ALREVLPALS SWRQGRQQRS TVDGWRYRIV WRPQPEPESG ELEGSWLIVV
     PADYLDDDLV QATSRGLGDR ARIMPVSATA DRAELLAQLA ALAGAADEPL HVLSLLALDD
     RDAGGHRGVP GSLLSTLALT QALAETEVKA RLWAVTQGAV STDACARGPE THPVSDPIRH
     PGQAAIWGLA RVFGLDHHER WGGLVDLPGT LDEHALRRFL SLLSGDGGSQ DEYAIRPSGV
     HVRRMVRAPL DPSAVVEPWQ PRGTVLITGG TGALGAHVAR ALAAGGAEHL VLAGRRGPDA
     PGSAELSAEL TALGARVTVA ACDVTDRAAV AKLLDSFTDE APLTAVVHTA GVVGEARPLD
     ETSLDDAMAA VHAKVSGAWH LDELLADHPL DAFVLFSSGA GVWGNGGQGP YAAANAALDA
     LAEWRRAQGR PATSLAWGAW AGGGMVDEAV AEQLRRRGVP AMDPGLAVHA LREAVDHGET
     TLVVADIRWD RFLPAYTVSG PRPLLDELPD VRQLLAGQEE QADEAGEKGS DLPDRLAALP
     EPKRKRMLLD LVRTHASAVL GHSSTDAVRP ARAFRELGFD SLTGVELRNR LNAATALTLP
     ATLVFDHPTP TALAEYLRDA LLPPEPDAGS EAPVLPELQQ VASALQAATD DDTRQALTDG
     LRGLLAHWEG QAPPPVETVD EELAEASDED MFDLIDRELG IG
//