ID J1RWK2_9ACTN Unreviewed; 1462 AA.
AC J1RWK2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:EJJ02907.1};
DE Flags: Fragment;
GN ORFNames=SU9_31533 {ECO:0000313|EMBL:EJJ02907.1};
OS Streptomyces auratus AGR0001.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1160718 {ECO:0000313|EMBL:EJJ02907.1};
RN [1] {ECO:0000313|EMBL:EJJ02907.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGR0001 {ECO:0000313|EMBL:EJJ02907.1};
RX PubMed=22965094; DOI=10.1128/JB.01155-12;
RA Han X., Li M., Ding Z., Zhao J., Ji K., Wen M., Lu T.;
RT "Genome Sequence of Streptomyces auratus Strain AGR0001, a Phoslactomycin-
RT Producing Actinomycete.";
RL J. Bacteriol. 194:5472-5473(2012).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJJ02907.1}.
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DR EMBL; AJGV01000203; EJJ02907.1; -; Genomic_DNA.
DR STRING; 1160718.SU9_31533; -.
DR eggNOG; COG0300; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_16_10_11; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 854..929
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 952..1380
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 812..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1381..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1394..1410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1462
FT /evidence="ECO:0000313|EMBL:EJJ02907.1"
SQ SEQUENCE 1462 AA; 152759 MW; 06E44709E34F923F CRC64;
MEPAAVVGHS QGEIAAACVA GALSLADGAR VVALRSKAIR ALSGRGGMVS VALPSSDVSD
LIKPWNGRVS VAAVNGPSSV VVSGDADALD ELMDGCKERE VRARRIEVDY ASHSAHVESI
REELLEVLAP VVPRPAEVPL FSTVRGEWLD AAEMDAGYWF TNLRRTVEFA PAIEALVAAG
HRTFVEVSPH PVLTVPLQET VEDEGADAVV TGTLRRDDGG LARLYTSLGV LYAHGVDVDW
SPAFADRRPH RVELPTYAFQ RQRFWLEPDA PAVAASPEEE AFWTAVGDQD AATLAGTLGL
PGAEALDEVL PALSSWHRNR RQRGTADGWR YRVVWRPLTE PAARQLDGEW LVVVPAGYED
DALVHGAREA LAEAGARTHS LTVDDRAGLA DLLRPGPGPF AGVLSLLALD ERPDRTHPCV
PTGLSLTLAL LQALGDAGID APLWCVTRGA VGIGTTAEAA TGGSAGEHDA PTNPDQAGIW
GLGRVAALEH PERWGGLIDL PGRAGGQTAA EGRTAADGQE VALLARILAA GDDEDQLAVR
GSALFGRRLL PAPVAGKPPR RSWRPRGTVL VTGGTGALGA HIARWLAADG AEHLVLTGRR
GADVPGVAAL CSELRDQGVR VTVAGCDLAD RQAVAELVRQ IERDGEPVRA VVHAAGVSAL
GSLAEAGPAD LAAALAGKVA GADHLSSALD PAQLDAVVYF SSISGTWGVA DHGAYAAANA
LLDARAERGR ADGLPVLSVA WGPWAGGGMI ADSIHDVLRR RGVPVIDPDT ALTALQQALD
HDDTSIAVAD VDWRRFHSVF TSVRPSRLLT EIPQLAADED GDGPGDDGSG TDRGSARSPL
AEKLAGLDVR QRTAALLDLV REQVASVLGH DKTAPVDPER PFKELGFDSL TAVELRNRLS
RATGLRLPRT VVFDHPSPAA LAGYVGTQLT GAEESAAKPA AAPAPLPAPA DDDPIAIVAM
ACRYPGGVQS PEDLWRLVRE GVDAMSAFPT DRGWDLDGLY DPDADQPGRS YVRESGFLGD
AADFDAEFFG ISPREALAMD PQQRLLLETS WEVFERAGID PKSLRGSGTG VYMGVTDQEY
GNRLRMAAPE QIEGYLATGA ATSVASGRVA YTLGLEGPAV TVDTACSSSL VALHMAVRAL
RSGECSLAVA GAAMIMADPG PFIGFSRQRG LARDGRCKPF SAAADGFALS EGVGVLLVER
LSDARRNGHP VLAVVRGTAV NQDGASNGLT APNGPSQQRV IRAALADARL SAGEVDAVEA
HGTGTSLGDP IEAQALLATY GQERDAERPL WLGSVKSNIG HTQTVSGVAG VMKMVLAMRH
GELPATLHVD EPSPHVEWAS GAVELLTEAR PWTAEEDRPR RAGISSFGIS GTNAHVIVEQ
AEESGRAEQS DQAESADGGE SASSSSASGV GPVVPWVVSG RSADALVAQA ERLASRVAGT
GLSPVDVGWS LVASRSSFEH RA
//
