ID J1S354_9ACTN Unreviewed; 608 AA.
AC J1S354;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=SU9_011700 {ECO:0000313|EMBL:QTZ92057.1}, SU9_19772
GN {ECO:0000313|EMBL:EJJ05247.1};
OS Streptomyces auratus AGR0001.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1160718 {ECO:0000313|EMBL:EJJ05247.1};
RN [1] {ECO:0000313|EMBL:EJJ05247.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGR0001 {ECO:0000313|EMBL:EJJ05247.1};
RX PubMed=22965094; DOI=10.1128/JB.01155-12;
RA Han X., Li M., Ding Z., Zhao J., Ji K., Wen M., Lu T.;
RT "Genome Sequence of Streptomyces auratus Strain AGR0001, a Phoslactomycin-
RT Producing Actinomycete.";
RL J. Bacteriol. 194:5472-5473(2012).
RN [2] {ECO:0000313|EMBL:QTZ92057.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AGR0001 {ECO:0000313|EMBL:QTZ92057.1};
RA Wen M.-L., Han X.-L., Xiong J.;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC {ECO:0000256|ARBA:ARBA00005336, ECO:0000256|RuleBase:RU361161}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJGV01000118; EJJ05247.1; -; Genomic_DNA.
DR EMBL; CP072931; QTZ92057.1; -; Genomic_DNA.
DR RefSeq; WP_006605477.1; NZ_CP072931.1.
DR AlphaFoldDB; J1S354; -.
DR STRING; 1160718.SU9_19772; -.
DR KEGG; sauh:SU9_011700; -.
DR PATRIC; fig|1160718.3.peg.4005; -.
DR eggNOG; COG1472; Bacteria.
DR HOGENOM; CLU_008392_5_3_11; -.
DR OrthoDB; 9805821at2; -.
DR Proteomes; UP000009036; Chromosome.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 1.
DR Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 1.
DR InterPro; IPR019800; Glyco_hydro_3_AS.
DR InterPro; IPR002772; Glyco_hydro_3_C.
DR InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR InterPro; IPR001764; Glyco_hydro_3_N.
DR InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR30480:SF13; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR30480; BETA-HEXOSAMINIDASE-RELATED; 1.
DR Pfam; PF00933; Glyco_hydro_3; 1.
DR Pfam; PF01915; Glyco_hydro_3_C; 1.
DR PRINTS; PR00133; GLHYDRLASE3.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52279; Beta-D-glucan exohydrolase, C-terminal domain; 1.
DR PROSITE; PS00775; GLYCOSYL_HYDROL_F3; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361161};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361161};
KW Reference proteome {ECO:0000313|Proteomes:UP000009036};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..608
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036283888"
FT DOMAIN 55..391
FT /note="Glycoside hydrolase family 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00933"
FT DOMAIN 431..608
FT /note="Glycoside hydrolase family 3 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01915"
SQ SEQUENCE 608 AA; 64007 MW; D0AFC00F8EF42439 CRC64;
MHSRRTVLTT AAAAAAAAAA GAAPAHAAAS PHGHRPPSPA TRARLRRLIS RMTPEEKVGQ
LFVMRVYGHS ATDPDPADVA ANQKEIGVAN AAELIAKYHV GGIIYFGWAH NTREPHQIAD
LSNGIQKAAA AQRVPVPLLI STDQEHGIVA RVGAPATLFP GAMALGAGRS RDDARTAGRI
AGEELFAMGI RQDYAPDADV NVNPANPVIG VRSFGADPQA VARMVAAEVT GYQGAGVAAC
AKHFPGHGDT DTDSHVGLPY IHHTAEEWER LDAPPFKAAI AAGIDSIMTA HIVVPAFDAR
EDPATLSRPI LTGILRERLG YDGVVVTDSL GMEGVRVKYG DARVPVLALK AGVDQLLNPP
DLSVAHAAVL KALADGELTE RDLDAKLMRI LLLKDRRGLF ANPYTTHRAV DRVVGTRSHL
AAADRIADRT TTLLRNDAGI LPLSRRRERR VLVVGFDAAA PSGTGGPPTT VLAKAFTELG
FTATALSTGL SPGRQQIDEA VAALAARDAV VVATYNVTAD SPQRKLVDAL LATGKPVVQL
AVRNPYDIAQ LAGVKAALAS YSWTDVELRA AARVIAGRRN PAGRLPVPIM RADTPTTALY
RIGHGLSY
//
