ID J2JTK4_9ACTN Unreviewed; 333 AA.
AC J2JTK4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Methyltransferase {ECO:0000313|EMBL:EJJ03758.1, ECO:0000313|EMBL:QTZ90218.1};
GN ORFNames=SU9_001100 {ECO:0000313|EMBL:QTZ90218.1}, SU9_27169
GN {ECO:0000313|EMBL:EJJ03758.1};
OS Streptomyces auratus AGR0001.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1160718 {ECO:0000313|EMBL:EJJ03758.1};
RN [1] {ECO:0000313|EMBL:EJJ03758.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGR0001 {ECO:0000313|EMBL:EJJ03758.1};
RX PubMed=22965094; DOI=10.1128/JB.01155-12;
RA Han X., Li M., Ding Z., Zhao J., Ji K., Wen M., Lu T.;
RT "Genome Sequence of Streptomyces auratus Strain AGR0001, a Phoslactomycin-
RT Producing Actinomycete.";
RL J. Bacteriol. 194:5472-5473(2012).
RN [2] {ECO:0000313|EMBL:QTZ90218.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AGR0001 {ECO:0000313|EMBL:QTZ90218.1};
RA Wen M.-L., Han X.-L., Xiong J.;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AJGV01000170; EJJ03758.1; -; Genomic_DNA.
DR EMBL; CP072931; QTZ90218.1; -; Genomic_DNA.
DR RefSeq; WP_006606942.1; NZ_CP072931.1.
DR AlphaFoldDB; J2JTK4; -.
DR STRING; 1160718.SU9_27169; -.
DR KEGG; sauh:SU9_001100; -.
DR PATRIC; fig|1160718.3.peg.5507; -.
DR eggNOG; COG2226; Bacteria.
DR HOGENOM; CLU_005533_4_1_11; -.
DR Proteomes; UP000009036; Chromosome.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:EJJ03758.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009036};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:EJJ03758.1}.
FT DOMAIN 24..96
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 127..313
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 245
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 333 AA; 35845 MW; 1FEBF46385446C9B CRC64;
MFKTTTDAEL AGNPIDEVIG STIRYAALTS AAKLGIFTAL QEGPKTLDEL AAAIGASTDG
TRAVADVAAV LGWLALEDGR YRNGPLAERW LGKDAEYDFT PALLWAYELT NVMWELPQAV
RDGKPAQSLW ERWADNPEAG RDFSAYMRIK SRLTVQPIVD AVPLPEGARR LLDLGGSHGL
HSMAMCERHP ELSATILDLP EALADTGAAI AKAGLADRIT LQRGSFLSGD LGTGYDVVFL
FEIVHNHTDE ENRDLIARAA KALRPGGRIV VLEDVRGEQL DEHNAAFSLA MYACSGDRTY
SLPEISGWLT DAGLSGVERI ALPSSVSLVV GTK
//
