ID J2JZI5_9ACTN Unreviewed; 444 AA.
AC J2JZI5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Diaminopimelate decarboxylase {ECO:0000313|EMBL:QTZ92309.1};
DE SubName: Full=Orn/DAP/Arg decarboxylase 2 {ECO:0000313|EMBL:EJJ05540.1};
GN ORFNames=SU9_013170 {ECO:0000313|EMBL:QTZ92309.1}, SU9_18311
GN {ECO:0000313|EMBL:EJJ05540.1};
OS Streptomyces auratus AGR0001.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1160718 {ECO:0000313|EMBL:EJJ05540.1};
RN [1] {ECO:0000313|EMBL:EJJ05540.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGR0001 {ECO:0000313|EMBL:EJJ05540.1};
RX PubMed=22965094; DOI=10.1128/JB.01155-12;
RA Han X., Li M., Ding Z., Zhao J., Ji K., Wen M., Lu T.;
RT "Genome Sequence of Streptomyces auratus Strain AGR0001, a Phoslactomycin-
RT Producing Actinomycete.";
RL J. Bacteriol. 194:5472-5473(2012).
RN [2] {ECO:0000313|EMBL:QTZ92309.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AGR0001 {ECO:0000313|EMBL:QTZ92309.1};
RA Wen M.-L., Han X.-L., Xiong J.;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR600183-50};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC {ECO:0000256|RuleBase:RU003737}.
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DR EMBL; AJGV01000106; EJJ05540.1; -; Genomic_DNA.
DR EMBL; CP072931; QTZ92309.1; -; Genomic_DNA.
DR RefSeq; WP_006605192.1; NZ_CP072931.1.
DR AlphaFoldDB; J2JZI5; -.
DR STRING; 1160718.SU9_18311; -.
DR KEGG; sauh:SU9_013170; -.
DR PATRIC; fig|1160718.3.peg.3703; -.
DR eggNOG; COG0019; Bacteria.
DR HOGENOM; CLU_026444_3_1_11; -.
DR OrthoDB; 9802241at2; -.
DR Proteomes; UP000009036; Chromosome.
DR GO; GO:0008836; F:diaminopimelate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR002986; DAP_deCOOHase_LysA.
DR InterPro; IPR022643; De-COase2_C.
DR InterPro; IPR022644; De-COase2_N.
DR InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR InterPro; IPR029066; PLP-binding_barrel.
DR PANTHER; PTHR43727; DIAMINOPIMELATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43727:SF3; DIAMINOPIMELATE DECARBOXYLASE; 1.
DR Pfam; PF02784; Orn_Arg_deC_N; 1.
DR Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR PRINTS; PR01181; DAPDCRBXLASE.
DR PRINTS; PR01179; ODADCRBXLASE.
DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR600183-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000009036}.
FT DOMAIN 42..287
FT /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02784"
FT DOMAIN 289..383
FT /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00278"
FT ACT_SITE 356
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
FT MOD_RES 62
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
SQ SEQUENCE 444 AA; 46408 MW; ED7F5F5EC5F28EB9 CRC64;
MNFTDRDRAV RAAVAEGLVG PAEPVAGLLD IAGIRRSAAE LRAAFEEFTA PGTPVLHAFA
VKAASLVPVL RLLAQEGLGC EVASPGELAL ARAAGVPVAR TVLDSPAKTR AELREALALG
IAVNADNPEE LARIDSLMAS APSSAPVGLR VNPQIGGGSI GAMSTATDTS KFGVGLRDEG
ARDWVVRSVL ARPWLTRLHA HVGSQGMPLE LMTAGVGALF VLAEEINERA GRRQIDTLDI
GGGLPVNFSS DAVTPTYREY VAQLHATVPG LLSGRYGLVT EFGRSLLAKH GTVLARVEYA
KSAGGRPIAV THAGAQVATR TVFAPESWPI RVAAYDAEGR PKTGAPVAQD VAGPCCFAGD
LVAENRPLPL LESGDHAALL DTGAYYYSTH FAYNSLPRPG IYGYAADPDG TVRFATVRTP
QTLEELTAES GGAHTESLRD LGRQ
//
