UniProt: J2LP98

Database: UniProt
Entry: J2LP98_9BURK

LinkDB:  J2LP98_9BURK 
Original site:  J2LP98_9BURK

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Ontology (7)   
   GO (7)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (35)   
   InterPro (20)   
   Pfam (8)   
   PROSITE (4)   
   SMART (3)   
Literature (1)   
   PubMed (1)   
All databases (45)   

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ID   J2LP98_9BURK            Unreviewed;      3729 AA.
AC   J2LP98;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Amino acid adenylation enzyme/thioester reductase family protein {ECO:0000313|EMBL:EJL94065.1};
GN   ORFNames=PMI16_00420 {ECO:0000313|EMBL:EJL94065.1};
OS   Herbaspirillum sp. CF444.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Herbaspirillum.
OX   NCBI_TaxID=1144319 {ECO:0000313|EMBL:EJL94065.1, ECO:0000313|Proteomes:UP000007296};
RN   [1] {ECO:0000313|EMBL:EJL94065.1, ECO:0000313|Proteomes:UP000007296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF444 {ECO:0000313|EMBL:EJL94065.1,
RC   ECO:0000313|Proteomes:UP000007296};
RX   PubMed=23045501; DOI=10.1128/JB.01243-12;
RA   Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA   Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT   "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT   sequences from diverse bacteria isolated from the rhizosphere and
RT   endosphere of Populus deltoides.";
RL   J. Bacteriol. 194:5991-5993(2012).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJL94065.1}.
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DR   EMBL; AKJW01000011; EJL94065.1; -; Genomic_DNA.
DR   RefSeq; WP_007875873.1; NZ_AKJW01000011.1.
DR   STRING; 1144319.PMI16_00420; -.
DR   PATRIC; fig|1144319.3.peg.418; -.
DR   eggNOG; COG1020; Bacteria.
DR   Proteomes; UP000007296; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd17646; A_NRPS_AB3403-like; 1.
DR   CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR   CDD; cd19531; LCL_NRPS-like; 3.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 1.10.1240.100; -; 1.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 3.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          49..471
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          673..751
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1244..1319
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2300..2375
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3369..3444
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3729 AA;  416741 MW;  AC6510ECEF27D4D6 CRC64;
     MDTFEKLSVL EKGMMQSLNK NAKAEVAAPA AASVAAPAVL PTEASTVHLE PIAIIGMAGN
     FPACMTLQEF WAALDLDTSL IQETPDSRAA MSAPGTTVSK HWGGFIPDIA GFDADFFGIS
     ALDANVMDPR QRLLLMSVYH CLEDACCIPG SLAGSDTGVY VAAEEDQYAQ TMLLLGIDTR
     DGIGQSASML ANRISYHFDL RGPSESINAM CSGAAVALHR AVSALRTGEI SQAIVGAANL
     LLRPEPYDAL ERANLLNRTS TVASFGRQAN GHLRSEGVIS LLLKPLKQAE KDGDAIYAVI
     KNTAVNFNGR GGLSIGAPNP SAHADLVERC YDEAGIDPRD LGYIEAQGMG NPLSDSAEWR
     AFNRALENVA KKKNVTLPEQ YCRVSSLKPM IGHMEAASAL GAVAKIIRSF QNGKIHKIRG
     LNEINEDLEI AGQACRLATS TETWARTKQA RLAALHSFGT GGNNAHILLE EYQAALPPPG
     SRGHFPCLIP LSAKNPGQLS ALVKNLKKHI DENADLVLED VAFSLQTGRE MMNVRLGLLV
     HSLAELSEVL GKLARQDLSK PSSTIALNDV YFGCKDETEL TLSLLANDED MEKTIEAWMD
     KGKFGKLLSI WSKGLAINWK TLYGKGDAYL PRQKIRLPAY PFERRYHWFD ADREPNAIQR
     VPSRHAKNET QILSTGDEPA QYLVRFLSLR LRASAEIDLD IPMNRLGINS LVLLELKREL
     ASEFGYASSI LHLMSDTTSI RRLAEEIKLN KPHAEQETPT VPTIKDQASR YALSRNQRAL
     WFIQQLSPTS SAYNISYAIH LNHAIHLPTL ASALSRVMAR HSILRARFHA DVLLEPYFIL
     EASHDLPLKH IDATTWTEQE IENCLAQEAD APFDLGHDGV CRMALIETDA TKENLFVFSV
     HHIAWDYLSF DILMKELGHF YAPASSTFPE ELPWQYADYI NWEKQFLLGE KHALSKQYWC
     DKLKGDLPTL NLPTDYPRPV IQTYRGETYC HAIDKPTCDR VHELSKSRGI TPYMILLSSF
     QVLLNRYTAQ DDILIGLPAA GRDASETRNL IGYFVNPVVL RIPFKSSISF DDLLLACRTE
     VLETLEHQQY SLEQLVNDLA IERDPGRPLL FQVLVNWQSL RSTDISDNPS QMWFSQVTGT
     QRGAAFDITL NLLEHDSHLE CQWVYNTSLF CQETIARMAH HFSSLLNSAL RNPESALADL
     EMPDETGHQF LTRRDFVATR PSEIAFKTHA GNVEDGLPSS AEPRALSPVE EKLRSIWSEI
     LACRQIGVTD SFFRLGGHSL LAMLVMSRVR EQFDLELTLD SLFQFPTIAS FAKLIERELQ
     IQKQDKSAEI VHSEHPITLM SYAQNRIWFL DQLVPDNLTY SVPLNLEIEG EIDAGILETC
     FKMICQRHRI LNSYYPIKEQ QAYTAYREAE FKLAVFEAEQ EAAALSYVQK PFNLLRGPLF
     RAALVRYSTE KNALYLCMHH IISDGWSLGI LMDEIAEIYD ALLGRREIRL PALPIQYADY
     VEWQRDQFTR PSSQHQLAYW KQQLEGAPPL FHPPLDYPRP PVPAFKGASV KFDIDKTLTD
     KLNALAQAQD ATLFMVLLAA FGIQLARYTG GTDVVIGSPI AGRQNSQVES LIGLFLNTIV
     LRLDYSGAPG FTGFLGRVRK TCLDAYTHQD VPFDRLVEEL QPDRNLAHSP LFQVMFVLQN
     QKMNPPGFGQ SKSRFQRLEN PTAKFDLTLS LDESEDGLHT SFEYNVDLFS AASVERFALH
     FKELLHTLME NPEADHFDYC ALSEQDAAQL RAWNDTAIDY PKEQQLLPEL FLSQVRRTPD
     RIALTFEGEQ LSYKLLNQRA NRLAACLRRH GVTPNVVVGI CMQRSIELVV GLLAIQKAGG
     AYLPLDPSYP DARLRYMMDD ARITLLLTHP AVAQSVSSFS GTVVSLDGDA IDDGQHADDA
     WSEDDCPNPA SPEHLAYVIY TSGSTGNPKG VGNSHEGIFN RLYWMQQTFP VLEGDAVLQK
     TPFGFDVSVW EFFLPLLFGG RLVIAKPNGH QDPAYLVRLI REQNVTHLHF VPSMLEIFSR
     EKNIETLDSI KYLFCSGEAL SFDLRTRFLK RLPIALHNLY GPTEAAVDVS HCPCGPDEDL
     DLIPIGKPIA NIQLHIVDPH CNPVPIGVVG ELLIGGIGLA RGYVNRPALT AEKFIPDPFS
     AEPGARLYKT GDLARYLSDG NIQYLGRIDN QVKIRGFRIE LGEIENVILE HPNVVECTVI
     VQTNSELDKR LIAFIVTGGK SLDANTLHIW GAERLQSYMV PSAFIDIEQM PLNANGKVDR
     SRLVQRARDL RDTGNVEHAA PKSDQEALLS EIWCDILKLD SVSVRSDFFA LGGHSLLAMQ
     VVSRIRDVFF VELPLHVLFQ NPTIEYMAAQ IDTQRFAQAL PAITPVADEE VPLSYAQTRF
     WFLDQLEGQS SNYNMAIAIR FDGPLHQPAL LNALRSLVER HKALRSYFIS KDGMPYLGFT
     DSAFEIPTRQ LDHLTPEARS ARLDELIAEE AKTAFVLADG GLFRASLLQL GKESHVLMVT
     MHHIISDGWS IGILMNDLRE YYAAYSEEKP ILLPDLPIEY GDFSAWQRQY FDRDYLAQQI
     NYWKNQLQSA PELLQLPTDF PRPPVQTTNG SEWRFTLDKS TKIRLEALSQ QEGATLFMTL
     LSAFSLLLGR YSGAEDIVIG SLVAGRNLSQ IETVVGVFVN TIALRIDLSD SPDFSALLKR
     VKEITLGAYS HQDVPFDRLV QELRPERNLS FSPLFQVMFV LQNAPMELLE LPGLQATPLM
     QHNKTSKFDI LFSMEENHKG MECILEYNSD LFKESTMQRF GEQFLLLVDA ILDAPDAPVH
     SHAIQTLGEK ELLATWRAAL PSVPAHVQSL PAIFEHAVQK APESIALVLE DEAITYDQLN
     RRANRLAHQL RAMGVGPDFL VGICLERSTD MIVAILAVLK AGGAYVPLDP AYPDSSLQFM
     VRDAALAIIV TTGPLTSKFG TGAETASLLL IDQDIQATNE QNPDWHIDPE HLAYVIYTSG
     STGTPKGVLV THANVSRLFS ATRPWFEFNE HDVWTLFHSY AFDFSIWEIW GAFVHGARLV
     IVPYMTSRSP LDFYQLLIRQ KVTVLSQTPS AFRQLMNADN ELDQTGETAL RYVIFGGEAL
     DLEKLRPWLE RHGDQEPQLV NMYGITETTV HVTCHPITLS DLEHPVSNIG VPIADLQVHI
     LDQSLKPVPL GAVGEMHIAG AGLARGYLNR PELTAQRFIA YPDGLENREQ NPRLYKSGDL
     GRFLPDGKIE YLGRIDNQVK IRGFRIELEE IEAVLLKAEN VIESVVIVVG AASEEKQLLA
     FVCADTPELI DINAIRRFAG QRLPVHMVPQ AYVVLDTIPL TRNGKVDRAL LAKISKDKYQ
     RVKEVEYVAP RDGLELRMCQ VWEDLLQVKP IGMTDNFFDL GGHSLVAVTL MSRIAQKFNQ
     KLPLASLFQN ATVEKLSNLL KGQNGDRYFT SLVSVNANGS KLPFFCFPGA GGSVVYLYEL
     ARQLGDDQPF YGLQAVGLDG ETDPLEDVKD MAAYWLEEVL KIHPEGPFLL GGHSFGGKIA
     FELAQQLIRR GREVALVVVL GTTAPHPDMV PIAQDWEGTR FLPELGKVME EYLERPLGIT
     EELLSTMSEP EQLEYVKNIL IAANWLPPEI ETKQFLGIVN VYRTNVSADY QPQNAVELDQ
     LVLVKGDTEK QYWPIQNEPE WGWDRFAKQV TIHITPGSHT SMLANPNVQS LAHYLRDCFT
     QASTVAEPL
//

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